NOP9_CANAL
ID NOP9_CANAL Reviewed; 720 AA.
AC Q59QH0; A0A1D8PD69;
DT 03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2017, sequence version 2.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Nucleolar protein 9;
DE AltName: Full=Pumilio domain-containing protein NOP9;
GN Name=NOP9; OrderedLocusNames=CAALFM_C104040CA;
GN ORFNames=CaO19.11959, CaO19.4479;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC -!- FUNCTION: RNA-binding nucleolar protein required for pre-rRNA
CC processing. Involved in production of 18S rRNA and assembly of small
CC ribosomal subunit (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NOP9 family. {ECO:0000305}.
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DR EMBL; CP017623; AOW26079.1; -; Genomic_DNA.
DR RefSeq; XP_711973.2; XM_706880.2.
DR AlphaFoldDB; Q59QH0; -.
DR SMR; Q59QH0; -.
DR STRING; 237561.Q59QH0; -.
DR GeneID; 3646429; -.
DR KEGG; cal:CAALFM_C104040CA; -.
DR CGD; CAL0000182236; orf19.11959.
DR VEuPathDB; FungiDB:C1_04040C_A; -.
DR eggNOG; KOG2188; Eukaryota.
DR HOGENOM; CLU_008720_1_1_1; -.
DR InParanoid; Q59QH0; -.
DR OrthoDB; 238378at2759; -.
DR PRO; PR:Q59QH0; -.
DR Proteomes; UP000000559; Chromosome 1.
DR GO; GO:0030686; C:90S preribosome; IBA:GO_Central.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0030688; C:preribosome, small subunit precursor; IBA:GO_Central.
DR GO; GO:0032040; C:small-subunit processome; IEA:EnsemblFungi.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0000480; P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR GO; GO:0000447; P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR GO; GO:0000472; P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR GO; GO:0000056; P:ribosomal small subunit export from nucleus; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 3.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR040000; NOP9.
DR InterPro; IPR001313; Pumilio_RNA-bd_rpt.
DR PANTHER; PTHR13102; PTHR13102; 1.
DR SMART; SM00025; Pumilio; 8.
DR SUPFAM; SSF48371; SSF48371; 1.
DR PROSITE; PS50302; PUM; 7.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing.
FT CHAIN 1..720
FT /note="Nucleolar protein 9"
FT /id="PRO_0000407803"
FT REPEAT 95..130
FT /note="Pumilio 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00317"
FT REPEAT 131..166
FT /note="Pumilio 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00317"
FT REPEAT 206..242
FT /note="Pumilio 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00317"
FT REPEAT 290..331
FT /note="Pumilio 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00317"
FT REPEAT 339..377
FT /note="Pumilio 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00317"
FT REPEAT 379..415
FT /note="Pumilio 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00317"
FT REPEAT 530..567
FT /note="Pumilio 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00317"
FT REPEAT 572..610
FT /note="Pumilio 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00317"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 165..190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 658..720
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 170..190
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 658..712
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 720 AA; 83387 MW; 759B2FE783047DFC CRC64;
MGKTKSRGRR AEKKNKKNEP GFNEDVSNLD SDVTITNQEP LSSSMSSTSG IPNTFFGLVD
NNELDYFKQA ESTLNINAFE TDEERQGFIN SVLEEAQGKE LKLVTNQICS KLMERLILFA
NHNQLKKIFK QFQNHFVSLA FHKYASHVLE TLLVRSAALI EKELTQTDEE KLEEAEEEEA
EEEEAEEDSL NNDVPMEDLF ISMLNEFKPH LTTMIDHSYA SHVLRLLILI LAGKELPSSV
TSNSTLRSKK SKIARKMIEI KDNEDFDRAF QTPQSFKNEL REYCQTIIVG LDTKSARELS
IHKIGSPVLQ LLIQVEGLVD RERSFWHLIF AKDSEGKDSV EESFVEYLLS ESVGSHFLES
IIKNDGARPK YIERLYKLYM KDRVLKLAKR STTGVYIIQA LLFKLKPVEV EYILDQIIPE
LAELISIAEN QNLDLANKLI DASISRGNYR RDEIINQLFI KFAPNYDIEN PSDNTSTEFI
ENILQLTGST LGNTRDDWPT AEERKRALFL EKLMEYDYKF VICTWFNFMA LPIERFVQMC
FHGVFCHVVE KALIVEPEEP KPIQILRKRL LNIFQGQIVG LACNSYGSHI VDSLWNFTVL
LPMYKDRIAS ELLGDSNKVK ESTYGRLVWK NWGMELFVRK KYDWKALIKQ QEQEYYGETE
DSTEKRAKKP IELKMERLAE EKRRQEEMAE RAQSGYTKRK LEEATGTASE KKQKLRGRRR
