ID   NOP9_CANTT              Reviewed;         705 AA.
AC   C5MFB4;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 47.
DE   RecName: Full=Nucleolar protein 9;
DE   AltName: Full=Pumilio domain-containing protein NOP9;
GN   Name=NOP9; ORFNames=CTRG_04757;
OS   Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=294747;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-3404 / T1;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: RNA-binding nucleolar protein required for pre-rRNA
CC       processing. Involved in production of 18S rRNA and assembly of small
CC       ribosomal subunit (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NOP9 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; GG692400; EER31974.1; -; Genomic_DNA.
DR   RefSeq; XP_002550459.1; XM_002550413.1.
DR   AlphaFoldDB; C5MFB4; -.
DR   SMR; C5MFB4; -.
DR   STRING; 5482.XP_002550459.1; -.
DR   PRIDE; C5MFB4; -.
DR   EnsemblFungi; EER31974; EER31974; CTRG_04757.
DR   GeneID; 8298110; -.
DR   KEGG; ctp:CTRG_04757; -.
DR   VEuPathDB; FungiDB:CTRG_04757; -.
DR   eggNOG; KOG2188; Eukaryota.
DR   HOGENOM; CLU_008720_1_1_1; -.
DR   OrthoDB; 238378at2759; -.
DR   Proteomes; UP000002037; Unassembled WGS sequence.
DR   GO; GO:0030686; C:90S preribosome; IEA:EnsemblFungi.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0030688; C:preribosome, small subunit precursor; IEA:EnsemblFungi.
DR   GO; GO:0032040; C:small-subunit processome; IEA:EnsemblFungi.
DR   GO; GO:0003723; F:RNA binding; IEA:EnsemblFungi.
DR   GO; GO:0000480; P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR   GO; GO:0000447; P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR   GO; GO:0000472; P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR   GO; GO:0000056; P:ribosomal small subunit export from nucleus; IEA:EnsemblFungi.
DR   Gene3D; 1.25.10.10; -; 3.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR040000; NOP9.
DR   InterPro; IPR001313; Pumilio_RNA-bd_rpt.
DR   PANTHER; PTHR13102; PTHR13102; 1.
DR   SMART; SM00025; Pumilio; 8.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing.
FT   CHAIN           1..705
FT                   /note="Nucleolar protein 9"
FT                   /id="PRO_0000407807"
FT   REPEAT          86..121
FT                   /note="Pumilio 1"
FT   REPEAT          122..157
FT                   /note="Pumilio 2"
FT   REPEAT          188..224
FT                   /note="Pumilio 3"
FT   REPEAT          272..308
FT                   /note="Pumilio 4"
FT   REPEAT          321..359
FT                   /note="Pumilio 5"
FT   REPEAT          361..397
FT                   /note="Pumilio 6"
FT   REPEAT          512..549
FT                   /note="Pumilio 7"
FT   REPEAT          554..592
FT                   /note="Pumilio 8"
FT   REGION          1..43
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          665..705
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        26..43
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        665..698
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   705 AA;  81850 MW;  37B8EBC065C3751D CRC64;
     MAKSKSRGRR AEKKSKKEES SLVHDSEVPV QESGENSTPS GVPNTFFGLV DSNELDYFKQ
     AESTLNINAF DSDEDRQGFI NSVLEEAQGK ELKLVTNQIC SKLMERLILF ANNKQLKKIF
     KQFSNHFVSL AFHKYSSHVL ETLLVRSAAL IEKELAQTEE EKHEEEEEGE DEKDDVPMED
     LFISMLNEFK PHLTTMIDHS YASHVLRLLL LILAGKELPS TTTSNSTLRS KKSKIARKMI
     EIKDNEDFNR AFQTPESFKN ELREYCQTIS AGLDTKSARE LSIHKIGSPV LQLLVQFEGL
     VDRERTFWHL IFCKDSEGKD STEESFVEYL LSDSVGSHFL ESIIKNDGAR PKYLERLYKL
     YMKDRVLKLA KRSTNGVYII QALLFKLKPV EVEFILDEII PELSELISIA ENQNLDLANK
     LIDASIIRGN YRRDEIIDQL FKKFAPNYNV ENPQDHTTTE FIENILQLQG STLGNTRDDW
     PTAEERKRAL FLEKLMEYDY KFVICTWFNF MALPIERFIQ MCFHGVFCHV VEKALIVEPE
     ESKKVQILRK RLLNIFQGQI VGLACNSYGS HIVDTLWNFT VLLPMYKDRI ASELFSESHK
     VKESTYGRLV WKNWGMELFS RKKYDWKALI KQQEVEYYGE DNEESTTSKR VKKPIELKLE
     RLAEEKRRKE EQAEKAQSGY IKRKLDELTG SGPEKKQKLR GRNRN