NOP9_KLULA
ID NOP9_KLULA Reviewed; 668 AA.
AC Q6CNC2;
DT 03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 25-MAY-2022, entry version 90.
DE RecName: Full=Nucleolar protein 9;
DE AltName: Full=Pumilio domain-containing protein NOP9;
GN Name=NOP9; OrderedLocusNames=KLLA0E13685g;
OS Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX NCBI_TaxID=284590;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: RNA-binding nucleolar protein required for pre-rRNA
CC processing. Involved in production of 18S rRNA and assembly of small
CC ribosomal subunit (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NOP9 family. {ECO:0000305}.
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DR EMBL; CR382125; CAG99654.1; -; Genomic_DNA.
DR RefSeq; XP_454567.1; XM_454567.1.
DR AlphaFoldDB; Q6CNC2; -.
DR SMR; Q6CNC2; -.
DR STRING; 28985.XP_454567.1; -.
DR PRIDE; Q6CNC2; -.
DR EnsemblFungi; CAG99654; CAG99654; KLLA0_E13685g.
DR GeneID; 2894466; -.
DR KEGG; kla:KLLA0_E13685g; -.
DR eggNOG; KOG2188; Eukaryota.
DR HOGENOM; CLU_008720_1_1_1; -.
DR InParanoid; Q6CNC2; -.
DR OMA; TPNGSHI; -.
DR Proteomes; UP000000598; Chromosome E.
DR GO; GO:0030686; C:90S preribosome; IEA:EnsemblFungi.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0030688; C:preribosome, small subunit precursor; IEA:EnsemblFungi.
DR GO; GO:0032040; C:small-subunit processome; IEA:EnsemblFungi.
DR GO; GO:0003723; F:RNA binding; IEA:EnsemblFungi.
DR GO; GO:0000480; P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR GO; GO:0000447; P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR GO; GO:0000472; P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR GO; GO:0000056; P:ribosomal small subunit export from nucleus; IEA:EnsemblFungi.
DR Gene3D; 1.25.10.10; -; 3.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR040000; NOP9.
DR InterPro; IPR001313; Pumilio_RNA-bd_rpt.
DR PANTHER; PTHR13102; PTHR13102; 1.
DR Pfam; PF00806; PUF; 2.
DR SMART; SM00025; Pumilio; 8.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing.
FT CHAIN 1..668
FT /note="Nucleolar protein 9"
FT /id="PRO_0000407814"
FT REPEAT 90..125
FT /note="Pumilio 1"
FT REPEAT 126..161
FT /note="Pumilio 2"
FT REPEAT 185..220
FT /note="Pumilio 3"
FT REPEAT 285..327
FT /note="Pumilio 4"
FT REPEAT 335..370
FT /note="Pumilio 5"
FT REPEAT 372..408
FT /note="Pumilio 6"
FT REPEAT 513..550
FT /note="Pumilio 7"
FT REPEAT 551..588
FT /note="Pumilio 8"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 637..668
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..31
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 643..660
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 668 AA; 77126 MW; A9F524582A87690B CRC64;
MARVRGRKLI KKLKKDEFHP EDNKTHDEPT VSHVNETAGG DNSDVSPNTF FGVLDSGELD
YFKKAESTLA IDTFENPDEK YQFINSVIEE SKGKELKLAT SQISSKLMER IIMESDETQL
KTIFKAFNGF YFNLACHKYS SHVLETLLVR GAAQVEKELL TPDFDSVDEG EFVTTESLFL
FLTNELQPNL RFMVSHQYAS HVLRILILVL SSKTLPSTVQ NNSTLRSKKS KIARKMIDIK
DNDNYNKIFK TPDSFKVVLR SMLSSIYTSF THGIPQGSGH FSEISLADVM KFREICVDKI
GSPVIQLVIQ VEGIFDRDRS YWHLIFKDSD EKDPKEESFV EYLLSDAVGS HFLQNVIAST
RIKYVERLYR LYMKDRIPKL AKRDTTAAFV LQSLLKVLNS KEVKEIMDEL VPDLSVLLNS
NMDFGTEIID ASIRHDNYLR DEIIEQLMKK YYPRESSDKN ILESCLQLSS STLGNTRDDW
PTAEERRKSL FLEKLIDYDD CFLNSTIDSM LNLPAERLLQ MPYHGVFSHV VEHVLQVKRV
AIIKRKLLLN VLCKDIVNLS CNAYGSHIVD KLWTFTAKLA MYKERIATAL CADSEKVKNS
VYGRQVWKNW SLELFVRKRY DWKKIVKEQE LEMFPDSKPL QPKTFKRPNN NNNSDVSPSF
KKSKFQKK
