NOP9_MOUSE
ID NOP9_MOUSE Reviewed; 636 AA.
AC Q8BMC4; Q3TW87; Q8BKR9; Q8BYV4; Q8VEF9; Q9D0C6; Q9D5A8;
DT 19-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Nucleolar protein 9;
DE AltName: Full=Pumilio domain-containing protein NOP9;
GN Name=Nop9;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo, Mesonephros, Placenta, Testis, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SIMILARITY: Belongs to the NOP9 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB29900.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAC34455.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BAC39042.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK011570; BAB27705.1; -; mRNA.
DR EMBL; AK015585; BAB29900.1; ALT_INIT; mRNA.
DR EMBL; AK032873; BAC28064.1; -; mRNA.
DR EMBL; AK037831; BAC29882.1; -; mRNA.
DR EMBL; AK050912; BAC34455.1; ALT_FRAME; mRNA.
DR EMBL; AK083861; BAC39042.1; ALT_INIT; mRNA.
DR EMBL; AK146020; BAE26838.1; -; mRNA.
DR EMBL; AK159798; BAE35379.1; -; mRNA.
DR EMBL; BC018523; AAH18523.1; -; mRNA.
DR CCDS; CCDS27126.1; -.
DR RefSeq; NP_080679.3; NM_026403.3.
DR AlphaFoldDB; Q8BMC4; -.
DR SMR; Q8BMC4; -.
DR BioGRID; 212472; 2.
DR IntAct; Q8BMC4; 1.
DR STRING; 10090.ENSMUSP00000019441; -.
DR iPTMnet; Q8BMC4; -.
DR PhosphoSitePlus; Q8BMC4; -.
DR EPD; Q8BMC4; -.
DR MaxQB; Q8BMC4; -.
DR PaxDb; Q8BMC4; -.
DR PRIDE; Q8BMC4; -.
DR ProteomicsDB; 295503; -.
DR Antibodypedia; 74; 34 antibodies from 12 providers.
DR Ensembl; ENSMUST00000019441; ENSMUSP00000019441; ENSMUSG00000019297.
DR GeneID; 67842; -.
DR KEGG; mmu:67842; -.
DR UCSC; uc007uao.2; mouse.
DR CTD; 161424; -.
DR MGI; MGI:1915092; Nop9.
DR VEuPathDB; HostDB:ENSMUSG00000019297; -.
DR eggNOG; KOG2188; Eukaryota.
DR GeneTree; ENSGT00390000004964; -.
DR HOGENOM; CLU_029199_1_0_1; -.
DR InParanoid; Q8BMC4; -.
DR OMA; TPNGSHI; -.
DR OrthoDB; 238378at2759; -.
DR PhylomeDB; Q8BMC4; -.
DR TreeFam; TF327254; -.
DR BioGRID-ORCS; 67842; 21 hits in 72 CRISPR screens.
DR ChiTaRS; Nop9; mouse.
DR PRO; PR:Q8BMC4; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; Q8BMC4; protein.
DR Bgee; ENSMUSG00000019297; Expressed in spermatocyte and 239 other tissues.
DR Genevisible; Q8BMC4; MM.
DR GO; GO:0030686; C:90S preribosome; IBA:GO_Central.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0030688; C:preribosome, small subunit precursor; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0000480; P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR GO; GO:0000447; P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR GO; GO:0000472; P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR GO; GO:0000056; P:ribosomal small subunit export from nucleus; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR040000; NOP9.
DR InterPro; IPR001313; Pumilio_RNA-bd_rpt.
DR PANTHER; PTHR13102; PTHR13102; 1.
DR SMART; SM00025; Pumilio; 5.
DR SUPFAM; SSF48371; SSF48371; 2.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome; Repeat; RNA-binding.
FT CHAIN 1..636
FT /note="Nucleolar protein 9"
FT /id="PRO_0000075928"
FT REPEAT 92..123
FT /note="Pumilio 1"
FT REPEAT 189..223
FT /note="Pumilio 2"
FT REPEAT 313..348
FT /note="Pumilio 3"
FT REPEAT 351..386
FT /note="Pumilio 4"
FT REPEAT 509..544
FT /note="Pumilio 5"
FT REPEAT 547..581
FT /note="Pumilio 6"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 222..242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 224..238
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 7
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q86U38"
FT CONFLICT 61
FT /note="A -> P (in Ref. 1; BAB29900/BAC39042)"
FT /evidence="ECO:0000305"
FT CONFLICT 110
FT /note="L -> V (in Ref. 1; BAC34455)"
FT /evidence="ECO:0000305"
FT CONFLICT 402
FT /note="P -> Q (in Ref. 1; BAB27705)"
FT /evidence="ECO:0000305"
FT CONFLICT 503
FT /note="L -> V (in Ref. 2; AAH18523)"
FT /evidence="ECO:0000305"
FT CONFLICT 525
FT /note="H -> N (in Ref. 1; BAB27705)"
FT /evidence="ECO:0000305"
FT CONFLICT 566
FT /note="D -> Y (in Ref. 1; BAC29882)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 636 AA; 70046 MW; AC4575FF7FA2756C CRC64;
MGLGPRSAHK ARRQFSGAGR RGRAARGSGR PPPGRDGYPR LPAAARAEQA PEALPHLSPE
ALGYFRRALS ALKVAPDAAE ERELMARNIL KEVEAQALAL ATNRTGSEML QELLGFSPLK
PLCRVWAALR PNLRFVACHR CGVHVLQSAL LQLPRLLRRP AEAEEEEEEE EEGGPSQTLE
ELVLGLAAEV CDDFLFFCGD THGSFVVRTL LQVLGGTLLE SERGKPRGSQ SSETQRTSAR
ECKPTDFEVP KTFLNRLQDL SACFLKDIAV FITDKISSFC LQVALQVLHQ KLPQHCAHLC
DAVIDYLSSR NSSADGSPLL LFLRDQTSSR LLEQVLLVLE AERLQRLYKD HFQGQLCSLA
EHPIANFPLQ RLLDAITSPE LLSLVFEELS PALEMVLAQG HPGVVVALVE ACRRVGTHQA
QVLQLLFEAF HCAEPPSRQA ACVPLFAALL AYEVYYELME EEGAVPAEHQ VEMATARALR
EVTVLGSLLL QHLLYFSNPG LVLRSLSALT GPQLLTLAQS PAGSHVFDAI LSSPSVTHKQ
RRRVLKTLKG QYVALACSRH GSRVLDAIWS GAALGARKEI AAELGEKNQE LIQDPFGHHV
ARNVALTTFL KRREAWEQQQ STVAKRRRAL SSILED
