NOP9_NEUCR
ID NOP9_NEUCR Reviewed; 775 AA.
AC Q7S5H0;
DT 03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2003, sequence version 1.
DT 25-MAY-2022, entry version 93.
DE RecName: Full=Nucleolar protein 9;
DE AltName: Full=Pumilio domain-containing protein nop9;
GN Name=nop9; ORFNames=NCU06118;
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
CC -!- FUNCTION: RNA-binding nucleolar protein required for pre-rRNA
CC processing. Involved in production of 18S rRNA and assembly of small
CC ribosomal subunit (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NOP9 family. {ECO:0000305}.
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DR EMBL; CM002242; EAA30744.1; -; Genomic_DNA.
DR RefSeq; XP_959980.1; XM_954887.2.
DR AlphaFoldDB; Q7S5H0; -.
DR SMR; Q7S5H0; -.
DR STRING; 5141.EFNCRP00000005319; -.
DR EnsemblFungi; EAA30744; EAA30744; NCU06118.
DR GeneID; 3876134; -.
DR KEGG; ncr:NCU06118; -.
DR VEuPathDB; FungiDB:NCU06118; -.
DR HOGENOM; CLU_008720_1_0_1; -.
DR InParanoid; Q7S5H0; -.
DR OMA; TPNGSHI; -.
DR Proteomes; UP000001805; Chromosome 7, Linkage Group VII.
DR GO; GO:0030686; C:90S preribosome; IBA:GO_Central.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0030688; C:preribosome, small subunit precursor; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0000480; P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR GO; GO:0000447; P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR GO; GO:0000472; P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR GO; GO:0000056; P:ribosomal small subunit export from nucleus; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR040000; NOP9.
DR InterPro; IPR001313; Pumilio_RNA-bd_rpt.
DR PANTHER; PTHR13102; PTHR13102; 1.
DR SMART; SM00025; Pumilio; 6.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing.
FT CHAIN 1..775
FT /note="Nucleolar protein 9"
FT /id="PRO_0000407820"
FT REPEAT 125..160
FT /note="Pumilio 1"
FT REPEAT 161..196
FT /note="Pumilio 2"
FT REPEAT 227..267
FT /note="Pumilio 3"
FT REPEAT 390..425
FT /note="Pumilio 4"
FT REPEAT 633..679
FT /note="Pumilio 5"
FT REGION 1..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 345..367
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 525..557
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 720..775
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..42
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 526..540
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 775 AA; 87513 MW; 38D136C19CB44333 CRC64;
MGKNRKSKRQ LVRDEKRAKK REREIEHEEE RDIKKQRREE AQQEALAPAA ADYVPPPLDG
TYDENAFSSA PEGRRGPNTN FEREFFGMLA EEEQEYFRHA DELLELNDFP SAEERDIFLQ
NVYKEMRGKE LKLASSQSCS RLMERLILLS NTRQKKSLFD AFGGHFISLV THRFASHCCE
KLFLQSAPVV TQELSGEYEQ EPLPEGEEET EAMKSSMEDL FLLTLDELEE HLGFLLSDRY
GSHAMRALLV ILSGRPLDQA GTKSLLQSRK KEYITVEGAA ANASELSSQI RAVPSSFTMA
IKKIIDDSTA TMDATALRVL AKHPTGNPTL QLLLELELTM FGKNKEKKDK KQKKDDDEAE
TKKEETQSEI SLLGMLVPDA PAAFADNTTQ AAEFVNSMIY DPIGSRLLET LITHCPGKIF
KGLQQHIFGP RIQSLLRNDI ACYPAIRVLN RLSREDLADA VEKSLPEMAS FVDKGRFNVI
KTLFERCNVR NGTDEINSLL KALTSAYGND WKNIVPKLCM LDEEVSEEEQ KPESTEEVGE
EEAEEKKKQQ QPKFQTQEAK NKAFMLNHGS QLVAALLTIP GQPSKAIQSS LAALKPAQVM
KMATTSHNTS SILIKALQTP AITPTFHKVL VSSLLPHVYE LATSQHGSAI LNAIITLPSK
PAEPNAPAVP FHMKENIISQ LAQYERDLRE TWLGRNVWRT WKGDLWSHRR HDWVRWAKET
DPETARVAAA PKKREEKEKE EAEKKPKGYL GKNFDPKKAK GLAGNKKFEK KEVSA
