ID   NOP9_PICGU              Reviewed;         697 AA.
AC   A5DBF4;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 2.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Nucleolar protein 9;
DE   AltName: Full=Pumilio domain-containing protein NOP9;
GN   Name=NOP9; ORFNames=PGUG_00609;
OS   Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539
OS   / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Meyerozyma.
OX   NCBI_TaxID=294746;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: RNA-binding nucleolar protein required for pre-rRNA
CC       processing. Involved in production of 18S rRNA and assembly of small
CC       ribosomal subunit (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NOP9 family. {ECO:0000305}.
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DR   EMBL; CH408155; EDK36511.2; -; Genomic_DNA.
DR   RefSeq; XP_001487232.1; XM_001487182.1.
DR   AlphaFoldDB; A5DBF4; -.
DR   SMR; A5DBF4; -.
DR   STRING; 4929.XP_001487232.1; -.
DR   EnsemblFungi; EDK36511; EDK36511; PGUG_00609.
DR   GeneID; 5128813; -.
DR   KEGG; pgu:PGUG_00609; -.
DR   VEuPathDB; FungiDB:PGUG_00609; -.
DR   eggNOG; KOG2188; Eukaryota.
DR   HOGENOM; CLU_008720_1_1_1; -.
DR   InParanoid; A5DBF4; -.
DR   OMA; TPNGSHI; -.
DR   OrthoDB; 238378at2759; -.
DR   Proteomes; UP000001997; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003729; F:mRNA binding; IEA:UniProt.
DR   GO; GO:0017148; P:negative regulation of translation; IEA:UniProt.
DR   GO; GO:0065008; P:regulation of biological quality; IEA:UniProt.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.10.10; -; 3.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR040000; NOP9.
DR   InterPro; IPR033133; PUM-HD.
DR   InterPro; IPR001313; Pumilio_RNA-bd_rpt.
DR   PANTHER; PTHR13102; PTHR13102; 1.
DR   Pfam; PF00806; PUF; 3.
DR   SMART; SM00025; Pumilio; 8.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS50303; PUM_HD; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; Ribosome biogenesis; rRNA processing.
FT   CHAIN           1..697
FT                   /note="Nucleolar protein 9"
FT                   /id="PRO_0000407827"
FT   REPEAT          105..140
FT                   /note="Pumilio 1"
FT   REPEAT          141..176
FT                   /note="Pumilio 2"
FT   REPEAT          198..234
FT                   /note="Pumilio 3"
FT   REPEAT          283..319
FT                   /note="Pumilio 4"
FT   REPEAT          332..369
FT                   /note="Pumilio 5"
FT   REPEAT          371..407
FT                   /note="Pumilio 6"
FT   REPEAT          523..557
FT                   /note="Pumilio 7"
FT   REPEAT          567..605
FT                   /note="Pumilio 8"
FT   REGION          22..54
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          654..697
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        31..51
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   697 AA;  80296 MW;  83E791A41C0D1391 CRC64;
     MSQPRCFMQD LIVSSSPENF SITSMGPKVR GRRAPNRETR EAKRQEDLVE DEQISEPTSN
     LTTPFFGLVD ASEIEYFKSA ESTLNVTSFE STEERDAFIN SVLDEASGKE LKLVTNQICS
     KLMERIILFG GDQQLISIFK SFSNHFVSLA HHKYSSHVLE TLLVRIAGLV EKELARSAED
     AADQEVTVEH LFITMMQEFY PHINEMITHQ YASHVLRLLI LILASKKLPS ALTANSTLRS
     KKSKIARKMI EIKDNEDFDR SFETPPSFKD ELKKVCKCIS ENKTMKEMRE LSIHKIASPV
     IQLVIQVEGL VDKERSVWHL VFLPESNSED PQEEAFVEHL LSDSVGSHFF ESIIKNGGAR
     PKYIERLYKL YMKDRIMKLA RRSTTGVYIV QALMFKLRPN EVEFILDEVI PELSNLVSIV
     DNQNIDLGRS VIDASISRSN YRRDDIISQL LSKFAPNFNP KNPSQNDNYD LLENTLLLSS
     STLGNTRDDW PTAEERRNAL FLEKLLDYDT SFLLAVWTSF LAMPKERFLQ MCFHGVFSHV
     VEHALAVIPA SIGESKEVNI LRKRLLNVFQ GSIVSLACNA YGSHIVDKLW SFTVLMKMYK
     ERFATEMKAE SHKVKESTYG RLVWKNWSME LFLRKKYDWS QLIKVQDEEY HNEGAEAETE
     RVKRPIELKM EQLAKKNEKS SLDSTNNDER NKRQRIR