ID   NOPC1_BOVIN             Reviewed;         192 AA.
AC   Q2TBJ0;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=NOP protein chaperone 1;
GN   Name=NOPCHAP1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Client-loading PAQosome/R2TP complex cofactor that selects
CC       NOP58 to promote box C/D small nucleolar ribonucleoprotein (snoRNP)
CC       assembly. Acts as a bridge between NOP58 and the R2TP complex via
CC       RUVBL1:RUVBL2. {ECO:0000250|UniProtKB:Q8N5I9}.
CC   -!- SUBUNIT: Interacts with NOP58, RUVBL1 and RUVBL2; the interactions are
CC       direct and NOPCHAP1 bridges the association of NOP58 with RUVBL1:RUVBL2
CC       even in absence of snoRNAs. The interactions with RUVBL1 and RUVBL2 are
CC       disrupted upon ATP binding. {ECO:0000250|UniProtKB:Q8N5I9}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8N5I9}.
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DR   EMBL; BC110124; AAI10125.1; -; mRNA.
DR   RefSeq; NP_001033778.1; NM_001038689.2.
DR   AlphaFoldDB; Q2TBJ0; -.
DR   SMR; Q2TBJ0; -.
DR   STRING; 9913.ENSBTAP00000028244; -.
DR   PaxDb; Q2TBJ0; -.
DR   PRIDE; Q2TBJ0; -.
DR   Ensembl; ENSBTAT00000028244; ENSBTAP00000028244; ENSBTAG00000021196.
DR   GeneID; 616791; -.
DR   KEGG; bta:616791; -.
DR   CTD; 121053; -.
DR   VEuPathDB; HostDB:ENSBTAG00000021196; -.
DR   VGNC; VGNC:49162; NOPCHAP1.
DR   eggNOG; ENOG502S6C1; Eukaryota.
DR   GeneTree; ENSGT00390000000376; -.
DR   HOGENOM; CLU_105671_0_0_1; -.
DR   InParanoid; Q2TBJ0; -.
DR   OMA; IIQMDVA; -.
DR   OrthoDB; 1478046at2759; -.
DR   TreeFam; TF333191; -.
DR   Proteomes; UP000009136; Chromosome 5.
DR   Bgee; ENSBTAG00000021196; Expressed in oocyte and 108 other tissues.
DR   ExpressionAtlas; Q2TBJ0; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0062064; F:box C/D snoRNP complex binding; ISS:UniProtKB.
DR   GO; GO:0000492; P:box C/D snoRNP assembly; ISS:UniProtKB.
DR   InterPro; IPR027921; NOPCHAP1.
DR   PANTHER; PTHR28674; PTHR28674; 1.
DR   Pfam; PF15370; DUF4598; 1.
PE   2: Evidence at transcript level;
KW   Chaperone; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..192
FT                   /note="NOP protein chaperone 1"
FT                   /id="PRO_0000263622"
FT   REGION          1..39
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          118..192
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..23
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        133..155
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        162..192
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         34
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8N5I9"
FT   MOD_RES         66
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8N5I9"
FT   MOD_RES         180
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8N5I9"
SQ   SEQUENCE   192 AA;  20946 MW;  04B19340728DE85C CRC64;
     MEVSGESHSG PSCSSSSRDG SGVSVSKELL MAGSGGRGGI WDRLFINSKP NSRKNSTLQT
     VRIERSPLLD QVRTFLPQMA QANEKLRKEM AAAPPGHFNI ENTDETLGQV IQMDVALFEM
     NQSHSKEEDS SEENSQDSSE ESSESEDEDD STSSEGEVTI DNIKLPHSED GKGKIEVLDS
     PASENKEKQE NK