NOPC1_MOUSE
ID NOPC1_MOUSE Reviewed; 185 AA.
AC Q9CX66; Q3TS58; Q3TV68;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=NOP protein chaperone 1;
GN Name=Nopchap1 {ECO:0000312|MGI:MGI:106381};
GN Synonyms=D10Wsu102e {ECO:0000312|MGI:MGI:106381};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Egg, Embryo, Kidney, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo, and Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-177, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney, Lung, Pancreas, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Client-loading PAQosome/R2TP complex cofactor that selects
CC NOP58 to promote box C/D small nucleolar ribonucleoprotein (snoRNP)
CC assembly. Acts as a bridge between NOP58 and the R2TP complex via
CC RUVBL1:RUVBL2. {ECO:0000250|UniProtKB:Q8N5I9}.
CC -!- SUBUNIT: Interacts with NOP58, RUVBL1 and RUVBL2; the interactions are
CC direct and NOPCHAP1 bridges the association of NOP58 with RUVBL1:RUVBL2
CC even in absence of snoRNAs. The interactions with RUVBL1 and RUVBL2 are
CC disrupted upon ATP binding. {ECO:0000250|UniProtKB:Q8N5I9}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8N5I9}.
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DR EMBL; AK020067; BAB31981.1; -; mRNA.
DR EMBL; AK049544; BAC33802.1; -; mRNA.
DR EMBL; AK147063; BAE27647.1; -; mRNA.
DR EMBL; AK160350; BAE35752.1; -; mRNA.
DR EMBL; AK162255; BAE36817.1; -; mRNA.
DR EMBL; BC050904; AAH50904.1; -; mRNA.
DR EMBL; BC094241; AAH94241.1; -; mRNA.
DR CCDS; CCDS24076.1; -.
DR RefSeq; NP_080855.1; NM_026579.3.
DR AlphaFoldDB; Q9CX66; -.
DR SMR; Q9CX66; -.
DR IntAct; Q9CX66; 1.
DR MINT; Q9CX66; -.
DR STRING; 10090.ENSMUSP00000020488; -.
DR iPTMnet; Q9CX66; -.
DR PhosphoSitePlus; Q9CX66; -.
DR EPD; Q9CX66; -.
DR jPOST; Q9CX66; -.
DR MaxQB; Q9CX66; -.
DR PaxDb; Q9CX66; -.
DR PeptideAtlas; Q9CX66; -.
DR PRIDE; Q9CX66; -.
DR ProteomicsDB; 285454; -.
DR Antibodypedia; 48157; 18 antibodies from 9 providers.
DR DNASU; 28109; -.
DR Ensembl; ENSMUST00000020488; ENSMUSP00000020488; ENSMUSG00000020255.
DR GeneID; 28109; -.
DR KEGG; mmu:28109; -.
DR UCSC; uc007gkg.2; mouse.
DR CTD; 121053; -.
DR MGI; MGI:106381; Nopchap1.
DR VEuPathDB; HostDB:ENSMUSG00000020255; -.
DR eggNOG; ENOG502S6C1; Eukaryota.
DR GeneTree; ENSGT00390000000376; -.
DR HOGENOM; CLU_105671_0_0_1; -.
DR InParanoid; Q9CX66; -.
DR OMA; IIQMDVA; -.
DR OrthoDB; 1478046at2759; -.
DR PhylomeDB; Q9CX66; -.
DR TreeFam; TF333191; -.
DR BioGRID-ORCS; 28109; 8 hits in 75 CRISPR screens.
DR ChiTaRS; D10Wsu102e; mouse.
DR PRO; PR:Q9CX66; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q9CX66; protein.
DR Bgee; ENSMUSG00000020255; Expressed in primary oocyte and 262 other tissues.
DR Genevisible; Q9CX66; MM.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0062064; F:box C/D snoRNP complex binding; ISS:UniProtKB.
DR GO; GO:0000492; P:box C/D snoRNP assembly; ISS:UniProtKB.
DR InterPro; IPR027921; NOPCHAP1.
DR PANTHER; PTHR28674; PTHR28674; 1.
DR Pfam; PF15370; DUF4598; 1.
PE 1: Evidence at protein level;
KW Chaperone; Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..185
FT /note="NOP protein chaperone 1"
FT /id="PRO_0000263624"
FT REGION 121..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 121..143
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 34
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N5I9"
FT MOD_RES 66
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N5I9"
FT MOD_RES 177
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CONFLICT 3
FT /note="F -> Y (in Ref. 1; BAE35752)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 185 AA; 19967 MW; 221BA55873D008EA CRC64;
MEFQGERGTG PGVSSSSVAC SQVTVSRELL TAGSEGSGGI WDQLLISSKP HPRKTSTLQT
VRMQRSPLLD QVQAFLPQMA QANEKLRREM AAAPAGHFNI ENIDETSGNI IQMDVALFEM
SRSDSKEEDS PEESSRDSSG DSSESEEDVC VPSEVTIENI KLPNAEGGKG KIEILDSPAS
KKKKQ
