ID   NORB_STAAR              Reviewed;         463 AA.
AC   Q6GGX2;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=Quinolone resistance protein NorB;
GN   Name=norB; OrderedLocusNames=SAR1448;
OS   Staphylococcus aureus (strain MRSA252).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=282458;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MRSA252;
RX   PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA   Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA   Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA   Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C.,
RA   Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z.,
RA   Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N.,
RA   Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A.,
RA   Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M.,
RA   Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
RT   "Complete genomes of two clinical Staphylococcus aureus strains: evidence
RT   for the rapid evolution of virulence and drug resistance.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
CC   -!- FUNCTION: Multidrug efflux pump that acts independently of NorA and is
CC       one of the factors that confers resistance against diverse quinolones
CC       and chemical compounds. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. TCR/Tet
CC       family. {ECO:0000305}.
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DR   EMBL; BX571856; CAG40445.1; -; Genomic_DNA.
DR   RefSeq; WP_000414703.1; NC_002952.2.
DR   AlphaFoldDB; Q6GGX2; -.
DR   SMR; Q6GGX2; -.
DR   KEGG; sar:SAR1448; -.
DR   HOGENOM; CLU_000960_28_3_9; -.
DR   OMA; RYPRFVG; -.
DR   OrthoDB; 1108236at2; -.
DR   Proteomes; UP000000596; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..463
FT                   /note="Quinolone resistance protein NorB"
FT                   /id="PRO_0000361958"
FT   TRANSMEM        17..37
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        86..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        107..127
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        142..162
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        165..185
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        201..221
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        230..250
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        273..293
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        299..319
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        334..354
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        357..377
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        403..423
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        435..455
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   463 AA;  49331 MW;  11D99C74BB8D6320 CRC64;
     MEKPSRETFE GNNKLLIGIV LSVITFWLFA QSLVNVVPIL EDSFNTDIGT VNIAVSITAL
     FSGMFVVGAG GLADKYGRIK LTNIGIILNI LGSLLIIISN IPLLLIIGRL IQGLSAACIM
     PATLSIIKSY YIGKDRQRAL SYWSIGSWGG SGVCSFFGGA VATLLGWRWI FILSIIISLI
     ALFLIKGTPE TKSKSISLNK FDIKGLVLLV IMLLSLNILI TKGSELGVTS LLFITILAIA
     IVSFSLFIVL EKRATNPLID FKLFKNKAYT GATASNFLLN GVAGTLIVAN TFVQRGLGYS
     SLQAGSLSIT YLVMVLIMIR VGEKLLQTFG CKKPMLIGTA VLIVGECLIS LTFLPEILYV
     ICCIIGYLFF GLGLGIYATP STDTAIANAP LEKVGVAAGI YKMASALGGA FGVALSGAVY
     AIVSNMTNID TGAMIALWLN AGMGILSFVI ILLLVPKQND TQL