ID   NORD_BRUA2              Reviewed;         633 AA.
AC   Q2YJT9;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-FEB-2006, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Protein NorD;
GN   Name=norD; OrderedLocusNames=BAB2_0952;
OS   Brucella abortus (strain 2308).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=359391;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2308;
RX   PubMed=16299333; DOI=10.1128/iai.73.12.8353-8361.2005;
RA   Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A.,
RA   Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E.;
RT   "Whole-genome analyses of speciation events in pathogenic Brucellae.";
RL   Infect. Immun. 73:8353-8361(2005).
CC   -!- FUNCTION: Part of the operon norEFCBQD encoding nitric oxide reductase.
CC       Essential virulence factor, probably involved in the detoxification of
CC       nitric oxide (NO) produced in the macrophages during the innate
CC       response against infection (By similarity). {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AM040265; CAJ13118.1; -; Genomic_DNA.
DR   RefSeq; WP_002966335.1; NZ_KN046823.1.
DR   AlphaFoldDB; Q2YJT9; -.
DR   STRING; 359391.BAB2_0952; -.
DR   EnsemblBacteria; CAJ13118; CAJ13118; BAB2_0952.
DR   GeneID; 3827266; -.
DR   KEGG; bmf:BAB2_0952; -.
DR   PATRIC; fig|359391.11.peg.637; -.
DR   HOGENOM; CLU_024042_0_0_5; -.
DR   OMA; GYYTRMG; -.
DR   PhylomeDB; Q2YJT9; -.
DR   Proteomes; UP000002719; Chromosome II.
DR   Gene3D; 3.40.50.410; -; 1.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   Pfam; PF00092; VWA; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; SSF53300; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Virulence.
FT   CHAIN           1..633
FT                   /note="Protein NorD"
FT                   /id="PRO_0000248305"
FT   DOMAIN          445..633
FT                   /note="VWFA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00219"
FT   REGION          232..270
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          290..314
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        232..246
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        255..270
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        291..314
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   633 AA;  70728 MW;  FE723B1ECE6579F4 CRC64;
     MLDFLELEET VGRAWHRLIG KTGSWPQYPD HAVQLVDIRQ RLAICFRGFG GDIAVQIAPA
     RARTSTHRLG LRQRMALGEE KLAQPLRDEA TLMLPPEIAL FPDRQLNYDL YVWLVGYMAV
     MPMDADALPE DALRRDLAAL QIAEQTVERA CRAFPGLKPR YKRLCAAILA ERPKRPLHRL
     EQQVEARILS LLKQGADLPD DALPTIFPHR GPAGYLPALP VPLWPGLMKR EEVAPRTGED
     EPVRNSQSEG AETGRQIAQR ERQDPRHADR SPFILNRFEK ILAMAEMVSV DRPSDDSDEQ
     NAKSADELDD LTLGERKGRP AARFRFDLDL PPEAVDRSLL TAELTYPEWD YRKGAYLPDH
     CAVLAAPVQE KEKPLELDAA AQSLVRRVRR QFEILRPGRE VLRAQLDGTD LDLDAVVRSR
     CDLAAGGQGS DRVHLMSRPQ ANDLAVTLLV DVSLSTDAWV DNRRVLDVEK EALLVLANGI
     AACGDRCSIL TFTSRRRSWV RVETVKDFDE SFGPTVEHRI AALKPGFYTR MGAAMRHATA
     KLAEQPNRKK LLLLLTDGKP NDVDHYEGRF ALEDSRRAAG EVRAKGVNVF AVTVDREASA
     YLPALFGRGG YALVANLAKL PVAMPAIYRM LAG