ID   NORD_BRUME              Reviewed;         633 AA.
AC   Q8YBA4;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Protein NorD;
GN   Name=norD; OrderedLocusNames=BMEII0996;
OS   Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=224914;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=16M / ATCC 23456 / NCTC 10094;
RX   PubMed=11756688; DOI=10.1073/pnas.221575398;
RA   DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T.,
RA   Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G.,
RA   Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E.,
RA   Selkov E., Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J.,
RA   Haselkorn R., Kyrpides N.C., Overbeek R.;
RT   "The genome sequence of the facultative intracellular pathogen Brucella
RT   melitensis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002).
CC   -!- FUNCTION: Part of the operon norEFCBQD encoding nitric oxide reductase.
CC       Essential virulence factor, probably involved in the detoxification of
CC       nitric oxide (NO) produced in the macrophages during the innate
CC       response against infection (By similarity). {ECO:0000250}.
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DR   EMBL; AE008918; AAL54238.1; -; Genomic_DNA.
DR   PIR; AC3634; AC3634.
DR   RefSeq; WP_004681531.1; NZ_GG703779.1.
DR   AlphaFoldDB; Q8YBA4; -.
DR   STRING; 224914.BMEII0996; -.
DR   EnsemblBacteria; AAL54238; AAL54238; BMEII0996.
DR   GeneID; 29595402; -.
DR   KEGG; bme:BMEII0996; -.
DR   PATRIC; fig|224914.52.peg.2366; -.
DR   eggNOG; COG4548; Bacteria.
DR   OMA; GYYTRMG; -.
DR   PhylomeDB; Q8YBA4; -.
DR   Proteomes; UP000000419; Chromosome II.
DR   Gene3D; 3.40.50.410; -; 1.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   Pfam; PF00092; VWA; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; SSF53300; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   3: Inferred from homology;
KW   Virulence.
FT   CHAIN           1..633
FT                   /note="Protein NorD"
FT                   /id="PRO_0000248306"
FT   DOMAIN          445..631
FT                   /note="VWFA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00219"
FT   REGION          232..270
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          290..313
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        232..246
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        255..270
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        292..313
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   633 AA;  70651 MW;  068F3C9EF1C40DA8 CRC64;
     MLDFLELEET VGRAWHRLIG KTGSWPQYPD HAVQLVDIRQ RLAICFRGFG GDIAVQIAPA
     RARTSTHRLG LRQRMALGEE KLAQPLRDEA TLMLPPEIAL FPDRQLNYDL YVWLVGYMAV
     MPMDADALPE DALRRDLAAL QIAEQTVERA CRAFPGLKPR YKRLCAAILA ERPKRPLHRL
     EQQVEARILS LLKQGADLPD DALPTIFPHR GPAGYLPALP VPLWPGLMKR EEVAPRTGED
     EPVRNSQSEG AETGRQIAQR ERQDPRHADR SPFILNRFEK ILAMAEMVSV DRPSDGSDEQ
     NAKSADELDD LTLGERKGRP AARFRFDLDL PPEAVDRSLL TAELTYPEWD YRKGAYLPNH
     CAVLAAPVQE KEKPLELDAA AQSLVRRVRR QFEILRPGRE VLRAQLDGTD LDLDAVVRSR
     CDLAAGGQGS DRVHLMSRPQ ANDLAVTLLV DVSLSTDAWV DNRRVLDVEK EALLVLANGI
     AACGDRCSIL TFTSRRRSWV RVETVKDFDE SFGPTVEHRI AALKPGFYTR MGAAMRHATA
     KLAEQPNRKK LLLLLTDGKP NDVDHYEGRF ALEDSRRAAG EVRAKGVNVF AVTVDREASA
     YLPALFGRGG YALVANLAKL PVALPAIYRM LAG