ID   NORD_BRUSU              Reviewed;         633 AA.
AC   Q8FX38; G0KF87;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Protein NorD;
GN   Name=norD; OrderedLocusNames=BRA0251, BS1330_II0248;
OS   Brucella suis biovar 1 (strain 1330).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=204722;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1330;
RX   PubMed=12271122; DOI=10.1073/pnas.192319099;
RA   Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F.,
RA   Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J.,
RA   Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R.,
RA   Nelson W.C., Ayodeji B., Kraul M., Shetty J., Malek J.A., Van Aken S.E.,
RA   Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L.,
RA   Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M.;
RT   "The Brucella suis genome reveals fundamental similarities between animal
RT   and plant pathogens and symbionts.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1330;
RX   PubMed=22038969; DOI=10.1128/jb.06181-11;
RA   Tae H., Shallom S., Settlage R., Preston D., Adams L.G., Garner H.R.;
RT   "Revised genome sequence of Brucella suis 1330.";
RL   J. Bacteriol. 193:6410-6410(2011).
RN   [3]
RP   FUNCTION.
RC   STRAIN=1330;
RX   PubMed=16495577; DOI=10.1128/iai.74.3.1973-1976.2006;
RA   Loisel-Meyer S., Jimenez de Baguees M.P., Basseres E., Dornand J.,
RA   Koehler S., Liautard J.-P., Jubier-Maurin V.;
RT   "Requirement of norD for Brucella suis virulence in a murine model of in
RT   vitro and in vivo infection.";
RL   Infect. Immun. 74:1973-1976(2006).
CC   -!- FUNCTION: Part of the operon norEFCBQD encoding nitric oxide reductase.
CC       Essential virulence factor, probably involved in the detoxification of
CC       nitric oxide (NO) produced in the macrophages during the innate
CC       response against infection. {ECO:0000269|PubMed:16495577}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE014292; AAN33453.1; -; Genomic_DNA.
DR   EMBL; CP002998; AEM19731.1; -; Genomic_DNA.
DR   RefSeq; WP_006191744.1; NZ_KN046805.1.
DR   AlphaFoldDB; Q8FX38; -.
DR   EnsemblBacteria; AEM19731; AEM19731; BS1330_II0248.
DR   GeneID; 45053321; -.
DR   KEGG; bms:BRA0251; -.
DR   KEGG; bsi:BS1330_II0248; -.
DR   PATRIC; fig|204722.21.peg.2726; -.
DR   HOGENOM; CLU_024042_0_0_5; -.
DR   OMA; GYYTRMG; -.
DR   PhylomeDB; Q8FX38; -.
DR   PRO; PR:Q8FX38; -.
DR   Proteomes; UP000007104; Chromosome II.
DR   Gene3D; 3.40.50.410; -; 1.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   Pfam; PF00092; VWA; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; SSF53300; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   4: Predicted;
KW   Virulence.
FT   CHAIN           1..633
FT                   /note="Protein NorD"
FT                   /id="PRO_0000248307"
FT   DOMAIN          445..631
FT                   /note="VWFA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00219"
FT   REGION          232..270
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          290..314
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        232..246
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        255..270
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        291..314
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   633 AA;  70684 MW;  E5829091C3E12BA4 CRC64;
     MLDFLELEET VGRAWHRLIG KTGSWPQYPD HAVQLVDIRQ RLAICFRGFG GDIAVQIAPA
     RARTSTHRLG LRRRMALGEE KLAQPLRDEA TLMLPPEIAL FPDRQLNYDL YVWLVGYMAV
     MPMDADALPE DALRRDLAAL QIAEQTVERA CRAFPGLKPR YKRLCAAILA ERPKRPLHRL
     EQQVEARILS LLKQGADLPD DALPTIFPHR GPAGYLPALP VPLWPGLMKR EEVAPRTGED
     EPVRNSQSEG AETGRQIAQR ERQDPRHADR SPFILNRFEK ILAMAEMVSV DRPSDDSDEQ
     NAKSADELDD LTLGERKGRP AARFRFDLDL PPEAVDRSLL TAELTYPEWD YRKGAYLPDH
     CAVLAAPVQE KEKPLELDAA AQSLVRRVRR QFEILRPGRE VLRAQLDGTD LDLDAVVRSR
     CDLAAGGQGS DRVHLMSRPQ ANDLAVTLLV DVSLSTDAWV DNRRVLDVEK EALLVLANGI
     AACGDRCSIL TFTSRRRSWV RVETVKDFDE SFGPTVEHRI AALKPGFYTR MGAAMRHATA
     KLAEQPNRKK LLLLLTDGKP NDVDHYEGRF ALEDSRRAAG EARAKGVNVF AVTVDREASA
     HLPALFGRGG YALVANLAKL PVALPAIYRM LAG