ID   NORM_ACIAD              Reviewed;         449 AA.
AC   Q6FEY7;
DT   29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Probable multidrug resistance protein NorM;
DE   AltName: Full=Multidrug-efflux transporter;
GN   Name=norM; OrderedLocusNames=ACIAD0429;
OS   Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC   Acinetobacter.
OX   NCBI_TaxID=62977;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33305 / BD413 / ADP1;
RX   PubMed=15514110; DOI=10.1093/nar/gkh910;
RA   Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L.,
RA   Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N.,
RA   Weissenbach J., Marliere P., Cohen G.N., Medigue C.;
RT   "Unique features revealed by the genome sequence of Acinetobacter sp. ADP1,
RT   a versatile and naturally transformation competent bacterium.";
RL   Nucleic Acids Res. 32:5766-5779(2004).
CC   -!- FUNCTION: Multidrug efflux pump. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC       2.A.66.1) family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR543861; CAG67371.1; -; Genomic_DNA.
DR   RefSeq; WP_004920318.1; NC_005966.1.
DR   AlphaFoldDB; Q6FEY7; -.
DR   SMR; Q6FEY7; -.
DR   STRING; 62977.ACIAD0429; -.
DR   EnsemblBacteria; CAG67371; CAG67371; ACIAD0429.
DR   GeneID; 45232925; -.
DR   KEGG; aci:ACIAD0429; -.
DR   eggNOG; COG0534; Bacteria.
DR   HOGENOM; CLU_012893_6_0_6; -.
DR   OMA; TGNQKVG; -.
DR   OrthoDB; 1415498at2; -.
DR   BioCyc; ASP62977:ACIAD_RS01985-MON; -.
DR   Proteomes; UP000000430; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR002528; MATE_fam.
DR   Pfam; PF01554; MatE; 2.
DR   PIRSF; PIRSF006603; DinF; 1.
DR   TIGRFAMs; TIGR00797; matE; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell inner membrane; Cell membrane; Ion transport; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..449
FT                   /note="Probable multidrug resistance protein NorM"
FT                   /id="PRO_0000164194"
FT   TRANSMEM        17..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        54..76
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        97..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        129..151
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        164..186
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        196..215
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        243..265
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        280..302
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        315..337
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        352..369
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        390..412
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        417..439
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   449 AA;  49013 MW;  D8DDFFE31164559E CRC64;
     MAKVAGFRFE LKQLFHLMWP ILITQFAQAG LGLIDTIMAG HLSANDLAAI AVGVGLWMPV
     MLLFSAIMIA TTPLVAEAKG ARTPEHIPVI VRQSLWVAVS LGVIAMLILQ LMPFLLPILG
     VPESLQPKAG LFLHAIGFGM PAVTMYAALR GYSEALGYPR PVTVISLLAL VVLVPLNYIF
     MYGIGPVPHL GSAGCGFATA ILQWLMLITL ASYIYRAKAY QSTQVFSHWE RINLTLVKRI
     LKLGLPIGLA VFFEVSIFST GAIVLSPLGD TLVAAHQIAM SVTSQLFMIP MSLAIALTIR
     VGMYYGEKNW VSMRLVQKLG LATATFFAMC TMSLIWFARP QIVAIYTQDP AVFDIALYLL
     LFAMAYQLMD AWQVGAAGCL RGMQDTKGPM WITLIAYWVV AFPVGTYLAR VAKMGPAGVW
     LGLITGLSIA CVLLLMRLYR NNHKLAQQS