ID   NORM_AGRFC              Reviewed;         465 AA.
AC   Q8UDF5; Q7CXP9;
DT   29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Probable multidrug resistance protein NorM;
DE   AltName: Full=Multidrug-efflux transporter;
GN   Name=norM; OrderedLocusNames=Atu2172; ORFNames=AGR_C_3941;
OS   Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens
OS   (strain C58)).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Agrobacterium;
OC   Agrobacterium tumefaciens complex.
OX   NCBI_TaxID=176299;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C58 / ATCC 33970;
RX   PubMed=11743193; DOI=10.1126/science.1066804;
RA   Wood D.W., Setubal J.C., Kaul R., Monks D.E., Kitajima J.P., Okura V.K.,
RA   Zhou Y., Chen L., Wood G.E., Almeida N.F. Jr., Woo L., Chen Y.,
RA   Paulsen I.T., Eisen J.A., Karp P.D., Bovee D. Sr., Chapman P.,
RA   Clendenning J., Deatherage G., Gillet W., Grant C., Kutyavin T., Levy R.,
RA   Li M.-J., McClelland E., Palmieri A., Raymond C., Rouse G.,
RA   Saenphimmachak C., Wu Z., Romero P., Gordon D., Zhang S., Yoo H., Tao Y.,
RA   Biddle P., Jung M., Krespan W., Perry M., Gordon-Kamm B., Liao L., Kim S.,
RA   Hendrick C., Zhao Z.-Y., Dolan M., Chumley F., Tingey S.V., Tomb J.-F.,
RA   Gordon M.P., Olson M.V., Nester E.W.;
RT   "The genome of the natural genetic engineer Agrobacterium tumefaciens
RT   C58.";
RL   Science 294:2317-2323(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C58 / ATCC 33970;
RX   PubMed=11743194; DOI=10.1126/science.1066803;
RA   Goodner B., Hinkle G., Gattung S., Miller N., Blanchard M., Qurollo B.,
RA   Goldman B.S., Cao Y., Askenazi M., Halling C., Mullin L., Houmiel K.,
RA   Gordon J., Vaudin M., Iartchouk O., Epp A., Liu F., Wollam C., Allinger M.,
RA   Doughty D., Scott C., Lappas C., Markelz B., Flanagan C., Crowell C.,
RA   Gurson J., Lomo C., Sear C., Strub G., Cielo C., Slater S.;
RT   "Genome sequence of the plant pathogen and biotechnology agent
RT   Agrobacterium tumefaciens C58.";
RL   Science 294:2323-2328(2001).
CC   -!- FUNCTION: Multidrug efflux pump. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC       2.A.66.1) family. {ECO:0000305}.
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DR   EMBL; AE007869; AAK87917.1; -; Genomic_DNA.
DR   PIR; AC2843; AC2843.
DR   PIR; D97620; D97620.
DR   RefSeq; NP_355132.1; NC_003062.2.
DR   RefSeq; WP_010972113.1; NC_003062.2.
DR   AlphaFoldDB; Q8UDF5; -.
DR   SMR; Q8UDF5; -.
DR   STRING; 176299.Atu2172; -.
DR   DNASU; 1134210; -.
DR   EnsemblBacteria; AAK87917; AAK87917; Atu2172.
DR   KEGG; atu:Atu2172; -.
DR   PATRIC; fig|176299.10.peg.2182; -.
DR   eggNOG; COG0534; Bacteria.
DR   HOGENOM; CLU_012893_6_3_5; -.
DR   OMA; EFWILLK; -.
DR   PhylomeDB; Q8UDF5; -.
DR   BioCyc; AGRO:ATU2172-MON; -.
DR   Proteomes; UP000000813; Chromosome circular.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR002528; MATE_fam.
DR   Pfam; PF01554; MatE; 2.
DR   PIRSF; PIRSF006603; DinF; 1.
DR   TIGRFAMs; TIGR00797; matE; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell inner membrane; Cell membrane; Ion transport; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..465
FT                   /note="Probable multidrug resistance protein NorM"
FT                   /id="PRO_0000164195"
FT   TRANSMEM        61..83
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        104..126
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        141..163
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        170..192
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        202..224
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        251..273
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        283..305
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        326..348
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        368..390
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        403..425
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        435..457
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   465 AA;  49726 MW;  3D276180F4F07BED CRC64;
     MSSSVVAETV PSGSGSWFSH FKATLVLGIP LIGAQLAQLG IHTTDMVIVG QLGAEKLAAM
     VLAGQFFFVV FIFGSGFSVA VVPMVAQAYG QGDATSARRS LRMGMWVAIA YWLLALPIFF
     NAERILVYLG QNPNVAALTG HYLAIAKFGL LPALLFYVLR GLVSAIGRAG IILYVTIIML
     VMNGLMAYVL VFGHFGLPAM GMNGAAVVAV IVNAFSFIFI VAYVQTREET KKYELFVRFW
     RPDWHALFEV LRLGLPISIT ILAEVTLFAA ASILMGQIGT VQLAAHGIAL QLASIAFMIP
     LGLSQAATVR VGVARGQGDF KNLIRASIMI YAIACGIALC GGILFAAVPE FLAKWFLDPK
     LPEAAEVLAY ASSLVVIAGI FQLVDGIQAV TAGLLRGLKD ARIPAMLALI SYWPIGLALA
     WTMAFPLGFG GRGVWFGFVI GLSTAAVLLT VRFVLLVKRE MKTAR