ID   NORM_ALIF1              Reviewed;         460 AA.
AC   Q5E4Y6;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Multidrug resistance protein NorM;
DE   AltName: Full=Multidrug-efflux transporter;
DE   AltName: Full=Na(+)/drug antiporter;
GN   Name=norM; OrderedLocusNames=VF_1415;
OS   Aliivibrio fischeri (strain ATCC 700601 / ES114) (Vibrio fischeri).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Aliivibrio.
OX   NCBI_TaxID=312309;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700601 / ES114;
RX   PubMed=15703294; DOI=10.1073/pnas.0409900102;
RA   Ruby E.G., Urbanowski M., Campbell J., Dunn A., Faini M., Gunsalus R.,
RA   Lostroh P., Lupp C., McCann J., Millikan D., Schaefer A., Stabb E.,
RA   Stevens A., Visick K., Whistler C., Greenberg E.P.;
RT   "Complete genome sequence of Vibrio fischeri: a symbiotic bacterium with
RT   pathogenic congeners.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:3004-3009(2005).
CC   -!- FUNCTION: Multidrug efflux pump that functions as a Na(+)/drug
CC       antiporter. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC       2.A.66.1) family. {ECO:0000305}.
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DR   EMBL; CP000020; AAW85910.1; -; Genomic_DNA.
DR   RefSeq; WP_011262007.1; NC_006840.2.
DR   RefSeq; YP_204798.1; NC_006840.2.
DR   AlphaFoldDB; Q5E4Y6; -.
DR   SMR; Q5E4Y6; -.
DR   STRING; 312309.VF_1415; -.
DR   PRIDE; Q5E4Y6; -.
DR   EnsemblBacteria; AAW85910; AAW85910; VF_1415.
DR   KEGG; vfi:VF_1415; -.
DR   PATRIC; fig|312309.11.peg.1429; -.
DR   eggNOG; COG0534; Bacteria.
DR   HOGENOM; CLU_012893_6_0_6; -.
DR   OMA; EFWILLK; -.
DR   OrthoDB; 1415498at2; -.
DR   Proteomes; UP000000537; Chromosome I.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR002528; MATE_fam.
DR   Pfam; PF01554; MatE; 2.
DR   PIRSF; PIRSF006603; DinF; 1.
DR   TIGRFAMs; TIGR00797; matE; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell inner membrane; Cell membrane; Ion transport; Membrane;
KW   Reference proteome; Sodium; Sodium transport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..460
FT                   /note="Multidrug resistance protein NorM"
FT                   /id="PRO_0000164245"
FT   TRANSMEM        18..38
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        94..114
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        126..146
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        159..179
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        185..205
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        242..262
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        276..296
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        315..335
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        349..369
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        391..411
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        415..435
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   460 AA;  50151 MW;  D4BAC94A5CF9A9A0 CRC64;
     MHRYQKEIVR LIKLSTPVLI ASVAQTGMGF VDTVMAGGVS ATDMAAVAIA ASVWLPSVLF
     GVGLLMALVP VVAQLNGSGK SKKVPFEIHQ GVYLALLTSI PIMLVLYNAG FIIAAMDVEP
     ELYEKTQGYL HAVLWAAPAF LLFQTLRSFC EGLSLTTPAM IIGFIGLAAN VPLNWMFVYG
     ELGAPALGGV GCGVATAIVY WLMFLTMTLY TFIAPKLRRV NLYENWNKPQ RKEIYRLFKL
     GLPVALSIFF EVTLFAAVAL LVSPLGSTVV AAHQVAINFS SLIFMIPMSI AVAVSIRVGH
     KLGEKDLDGA KVASYCGLAF GLLMACCTAI LTLIFREQIA YLYSDNQEVI TLAVSLMLLA
     AIYQCTDAVQ VVAAGALRGY KDMNAIFKCT FVSYWIVGLP SGYVLGMTDW IREPMGVYGF
     WFGFIGGLTT SAILLTCRLL WLQRNPTRID MEVDELQIMH