NORM_AROAE
ID NORM_AROAE Reviewed; 463 AA.
AC Q5NYX9;
DT 29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 04-JAN-2005, sequence version 1.
DT 25-MAY-2022, entry version 92.
DE RecName: Full=Probable multidrug resistance protein NorM;
DE AltName: Full=Multidrug-efflux transporter;
GN Name=norM; OrderedLocusNames=AZOSEA36100; ORFNames=ebA6316;
OS Aromatoleum aromaticum (strain EbN1) (Azoarcus sp. (strain EbN1)).
OC Bacteria; Proteobacteria; Betaproteobacteria; Rhodocyclales;
OC Rhodocyclaceae; Aromatoleum.
OX NCBI_TaxID=76114;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EbN1;
RX PubMed=15551059; DOI=10.1007/s00203-004-0742-9;
RA Rabus R., Kube M., Heider J., Beck A., Heitmann K., Widdel F.,
RA Reinhardt R.;
RT "The genome sequence of an anaerobic aromatic-degrading denitrifying
RT bacterium, strain EbN1.";
RL Arch. Microbiol. 183:27-36(2005).
CC -!- FUNCTION: Multidrug efflux pump. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC 2.A.66.1) family. {ECO:0000305}.
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DR EMBL; CR555306; CAI09735.1; -; Genomic_DNA.
DR RefSeq; WP_011239393.1; NC_006513.1.
DR AlphaFoldDB; Q5NYX9; -.
DR SMR; Q5NYX9; -.
DR STRING; 76114.ebA6316; -.
DR EnsemblBacteria; CAI09735; CAI09735; ebA6316.
DR KEGG; eba:ebA6316; -.
DR eggNOG; COG0534; Bacteria.
DR HOGENOM; CLU_012893_6_0_4; -.
DR OMA; TGNQKVG; -.
DR OrthoDB; 1415498at2; -.
DR Proteomes; UP000006552; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR002528; MATE_fam.
DR Pfam; PF01554; MatE; 2.
DR PIRSF; PIRSF006603; DinF; 1.
DR TIGRFAMs; TIGR00797; matE; 1.
PE 3: Inferred from homology;
KW Antiport; Cell inner membrane; Cell membrane; Ion transport; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..463
FT /note="Probable multidrug resistance protein NorM"
FT /id="PRO_0000164196"
FT TRANSMEM 59..81
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..124
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..161
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 173..195
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 200..222
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 251..273
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 288..310
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 323..345
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 360..377
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 397..419
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 429..451
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 463 AA; 49428 MW; F88F76A5E5F59D14 CRC64;
MSAPILFPLS APESSFTIAG RLFHHAWPVL VAQLLSMSML IADTVITGRY GTLDLAAVAV
GSGVYISIVM LLVGVLQAVA PTVAHHFGAR RVDAIGPALQ QGFWLALMLA LPGIALLAFP
GFLLELSSVP ADVAGKTRDY LLATAFGLPA VLLYRTFYAF NNALGRPRAL MMISFIVTST
HIPLAWALVH GAFGLPPLGA IGCGISTAIV NWIAFACGAG YLAHNRDYRP YRLFANWQPP
RRRDLLALLK LGIPMGLSTF IEVSSFTLIA LFAARLGAEA VAGHRVVANL AALIYMLPLA
ISIAILVLVG QAAGAREPAR ARATVRVGMG LTVGLVALIG VLLWVGREPV VALFSADPAV
RAVALGLVFY ICIYQIFDAV QTVAAHALRG YKVTFMPMLL HALCFWGIAL AGGYWLAFHA
PGREQSPTVA GFWEASVVAT ILASVLFGWL LRVVMRRPQN VQT
