NORM_BACAN
ID NORM_BACAN Reviewed; 453 AA.
AC Q81T85; Q6I1G6; Q6KVB3;
DT 29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 25-MAY-2022, entry version 112.
DE RecName: Full=Probable multidrug resistance protein NorM;
DE AltName: Full=Multidrug-efflux transporter;
GN Name=norM; OrderedLocusNames=BA_1402, GBAA_1402, BAS1295;
OS Bacillus anthracis.
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC Bacillus cereus group.
OX NCBI_TaxID=1392;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ames / isolate Porton;
RX PubMed=12721629; DOI=10.1038/nature01586;
RA Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T.,
RA Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R.,
RA Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M.,
RA Kolonay J.F., Beanan M.J., Dodson R.J., Brinkac L.M., Gwinn M.L.,
RA DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C.,
RA Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y.,
RA Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M.,
RA Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E.,
RA White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M.,
RA Hanna P.C., Kolstoe A.-B., Fraser C.M.;
RT "The genome sequence of Bacillus anthracis Ames and comparison to closely
RT related bacteria.";
RL Nature 423:81-86(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ames ancestor;
RX PubMed=18952800; DOI=10.1128/jb.01347-08;
RA Ravel J., Jiang L., Stanley S.T., Wilson M.R., Decker R.S., Read T.D.,
RA Worsham P., Keim P.S., Salzberg S.L., Fraser-Liggett C.M., Rasko D.A.;
RT "The complete genome sequence of Bacillus anthracis Ames 'Ancestor'.";
RL J. Bacteriol. 191:445-446(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Sterne;
RA Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K.,
RA Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R.,
RA Richardson P., Rubin E., Tice H.;
RT "Complete genome sequence of Bacillus anthracis Sterne.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Multidrug efflux pump. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC 2.A.66.1) family. {ECO:0000305}.
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DR EMBL; AE016879; AAP25345.1; -; Genomic_DNA.
DR EMBL; AE017334; AAT30498.1; -; Genomic_DNA.
DR EMBL; AE017225; AAT53615.1; -; Genomic_DNA.
DR RefSeq; NP_843859.1; NC_003997.3.
DR RefSeq; WP_000665392.1; NZ_WXXJ01000001.1.
DR RefSeq; YP_027564.1; NC_005945.1.
DR AlphaFoldDB; Q81T85; -.
DR SMR; Q81T85; -.
DR STRING; 261594.GBAA_1402; -.
DR DNASU; 1084137; -.
DR EnsemblBacteria; AAP25345; AAP25345; BA_1402.
DR EnsemblBacteria; AAT30498; AAT30498; GBAA_1402.
DR GeneID; 45021381; -.
DR KEGG; ban:BA_1402; -.
DR KEGG; bar:GBAA_1402; -.
DR KEGG; bat:BAS1295; -.
DR PATRIC; fig|198094.11.peg.1375; -.
DR eggNOG; COG0534; Bacteria.
DR HOGENOM; CLU_012893_6_0_9; -.
DR OMA; TGNQKVG; -.
DR Proteomes; UP000000427; Chromosome.
DR Proteomes; UP000000594; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR002528; MATE_fam.
DR Pfam; PF01554; MatE; 2.
DR PIRSF; PIRSF006603; DinF; 1.
DR TIGRFAMs; TIGR00797; matE; 1.
PE 3: Inferred from homology;
KW Antiport; Cell membrane; Ion transport; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..453
FT /note="Probable multidrug resistance protein NorM"
FT /id="PRO_0000164197"
FT TRANSMEM 13..34
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 49..71
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 92..114
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..151
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 164..183
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 193..215
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..266
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 286..308
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 317..339
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 359..381
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 388..410
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 420..442
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 453 AA; 49810 MW; CBC28A40CCF099F0 CRC64;
MKETNSFSQK LKQFVLLFFP IFVTQMSLFA MSFFDTTMSG HASPIDLAGV AIGTSIWIPV
STGLTGILMA TTPIVAQLVG SKKKEDVPHV IIQAVYLAIC ASFVVILIGL FTVTPILNGM
RLEEPVERIA AQFLSIIAIG IIPLFTYTVL RGFIDALGKT RTTMIITLLS LPINVVLNYV
LIFGNFGFPK LGGVGAAIAS AATYWCILII TVMIIRTKEP FASFNIFKQL YRPSLSSWKE
FLKLGVPIGF AIFFETSIFA AVTLMMSNFS TTTIAAHQAA MNFASLLYMT PLSLAMAMTI
AVGFEVGAKR YNNAKQYGFI GIGLALAFAL LYSILLYFFD DEIASIYTTD IQVHHLAKEF
LIFAILFQIS DAIATPVQGA LRGYKDVNVA LIMTLIAYWV IGLPLGYILA TYTDWAAKGY
WIGLIIGLAF GATFLLIRLF QVQRKYTTQN SRS
