ID   NORM_BACC1              Reviewed;         454 AA.
AC   Q73BB8;
DT   29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Probable multidrug resistance protein NorM;
DE   AltName: Full=Multidrug-efflux transporter;
GN   Name=norM; OrderedLocusNames=BCE_1501;
OS   Bacillus cereus (strain ATCC 10987 / NRS 248).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=222523;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10987 / NRS 248;
RX   PubMed=14960714; DOI=10.1093/nar/gkh258;
RA   Rasko D.A., Ravel J., Oekstad O.A., Helgason E., Cer R.Z., Jiang L.,
RA   Shores K.A., Fouts D.E., Tourasse N.J., Angiuoli S.V., Kolonay J.F.,
RA   Nelson W.C., Kolstoe A.-B., Fraser C.M., Read T.D.;
RT   "The genome sequence of Bacillus cereus ATCC 10987 reveals metabolic
RT   adaptations and a large plasmid related to Bacillus anthracis pXO1.";
RL   Nucleic Acids Res. 32:977-988(2004).
CC   -!- FUNCTION: Multidrug efflux pump. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC       2.A.66.1) family. {ECO:0000305}.
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DR   EMBL; AE017194; AAS40430.1; -; Genomic_DNA.
DR   RefSeq; WP_000665521.1; NC_003909.8.
DR   AlphaFoldDB; Q73BB8; -.
DR   SMR; Q73BB8; -.
DR   DNASU; 2752531; -.
DR   EnsemblBacteria; AAS40430; AAS40430; BCE_1501.
DR   GeneID; 59158332; -.
DR   KEGG; bca:BCE_1501; -.
DR   HOGENOM; CLU_012893_6_0_9; -.
DR   OMA; TGNQKVG; -.
DR   Proteomes; UP000002527; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR002528; MATE_fam.
DR   Pfam; PF01554; MatE; 2.
DR   PIRSF; PIRSF006603; DinF; 1.
DR   TIGRFAMs; TIGR00797; matE; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell membrane; Ion transport; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..454
FT                   /note="Probable multidrug resistance protein NorM"
FT                   /id="PRO_0000164198"
FT   TRANSMEM        13..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        47..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        90..112
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        132..154
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        166..188
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        193..215
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        244..266
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        286..308
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        317..339
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        359..381
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        388..410
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        420..442
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   454 AA;  50155 MW;  1A8694019781FEBE CRC64;
     MKETSTFSQK LKQFVLLFFP IFITQMSLFA MSFFDTTMSG HASPIDLAGV AIGTSIWIPV
     STGLTGILMA TTPIVAQLVG SKKKEDVPQV VIQAVYLAIC ASFVVMLIGF FAVTPILNGM
     RLEEPVERIA AQFLSIIAIG IIPLFTYTVL RGFIDALGKT RTTMIITLLS LPINVILNYV
     LIFGHFGFPK LGGVGAAIAS TATYWCILII TVMIIRTKEP FASFHIFKQL YRPSLSSWKE
     FLKLGVPIGF AIFFETSIFA AVTLMMSNFS TTTIAAHQAA MNFASLLYMT PLSLAMAMTI
     AVGFEVGAKR YNNAKQYGFI GIGLALAFAL LYSILLYFFD DEIASIYTTD IQVHHLAKEF
     LIFAILFQIS DAIATPVQGA LRGYKDVNVS LIMTLIAYWV IGLPLGYILA TYTDWAAKGY
     WIGLIIGLAF GATFLLIRLF QVQRKYTIEN RRSR