ID   NORM_BACCR              Reviewed;         452 AA.
AC   Q81G28;
DT   29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 107.
DE   RecName: Full=Probable multidrug resistance protein NorM;
DE   AltName: Full=Multidrug-efflux transporter;
GN   Name=norM; OrderedLocusNames=BC_1383;
OS   Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC
OS   15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=226900;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373
RC   / NCTC 2599 / NRRL B-3711;
RX   PubMed=12721630; DOI=10.1038/nature01582;
RA   Ivanova N., Sorokin A., Anderson I., Galleron N., Candelon B., Kapatral V.,
RA   Bhattacharyya A., Reznik G., Mikhailova N., Lapidus A., Chu L., Mazur M.,
RA   Goltsman E., Larsen N., D'Souza M., Walunas T., Grechkin Y., Pusch G.,
RA   Haselkorn R., Fonstein M., Ehrlich S.D., Overbeek R., Kyrpides N.C.;
RT   "Genome sequence of Bacillus cereus and comparative analysis with Bacillus
RT   anthracis.";
RL   Nature 423:87-91(2003).
CC   -!- FUNCTION: Multidrug efflux pump. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC       2.A.66.1) family. {ECO:0000305}.
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DR   EMBL; AE016877; AAP08365.1; -; Genomic_DNA.
DR   RefSeq; NP_831164.1; NC_004722.1.
DR   RefSeq; WP_000665560.1; NC_004722.1.
DR   AlphaFoldDB; Q81G28; -.
DR   SMR; Q81G28; -.
DR   STRING; 226900.BC_1383; -.
DR   EnsemblBacteria; AAP08365; AAP08365; BC_1383.
DR   KEGG; bce:BC1383; -.
DR   PATRIC; fig|226900.8.peg.1357; -.
DR   HOGENOM; CLU_012893_6_0_9; -.
DR   OMA; TGNQKVG; -.
DR   Proteomes; UP000001417; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0046677; P:response to antibiotic; IBA:GO_Central.
DR   InterPro; IPR002528; MATE_fam.
DR   Pfam; PF01554; MatE; 2.
DR   PIRSF; PIRSF006603; DinF; 1.
DR   TIGRFAMs; TIGR00797; matE; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell membrane; Ion transport; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..452
FT                   /note="Probable multidrug resistance protein NorM"
FT                   /id="PRO_0000164199"
FT   TRANSMEM        13..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        49..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        92..114
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        129..151
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        164..183
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        193..215
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        240..262
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        282..304
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        317..339
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        359..381
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        388..410
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        420..442
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   452 AA;  49579 MW;  0A2355E112236ED0 CRC64;
     MKETTSFSQK LKQFVLLFFP IFVTQMSLFA MSFFDTTMSG HASPTDLSGV AIGTSIWIPV
     STGLTGILMA TTPIVAQLVG SKKKEDVPHV VIQAVYLAIC ASFVVILIGF FVVSPILNGM
     RLEEPVERIA AQFLSIIAIG IIPLFTYTVL RGFIDALGKT RTTMIITLLS LPINVILNYL
     LIFGNFGFPK LGGVGAAIAS TATYWCILII TVIIIQTKEP FASFNIFKQL YRPSLSSWIA
     FLKLGVPIGF AIFFETSIFA AVTLMMSNFS TTTIAAHQAA MNFASLLYMT PLSLAMAMTI
     AVGFEVGAKR YDNAKQYGLI GIGLALAFAL LYSILLYFFD DQIASIYTTD AKVHHLAKEF
     LIFAILFQIS DAIATPVQGA LRGYKDVNVA LIMTLIAYWI IGLPLGYILA TYTEWAAKGY
     WIGLIIGLAF GAAFLLIRLF QVQRKYTTQN SR