ID   NORM_BACCZ              Reviewed;         453 AA.
AC   Q63DZ4;
DT   21-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Probable multidrug resistance protein NorM;
DE   AltName: Full=Multidrug-efflux transporter;
GN   Name=norM; OrderedLocusNames=BCE33L1269;
OS   Bacillus cereus (strain ZK / E33L).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=288681;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ZK / E33L;
RX   PubMed=16621833; DOI=10.1128/jb.188.9.3382-3390.2006;
RA   Han C.S., Xie G., Challacombe J.F., Altherr M.R., Bhotika S.S., Bruce D.,
RA   Campbell C.S., Campbell M.L., Chen J., Chertkov O., Cleland C.,
RA   Dimitrijevic M., Doggett N.A., Fawcett J.J., Glavina T., Goodwin L.A.,
RA   Hill K.K., Hitchcock P., Jackson P.J., Keim P., Kewalramani A.R.,
RA   Longmire J., Lucas S., Malfatti S., McMurry K., Meincke L.J., Misra M.,
RA   Moseman B.L., Mundt M., Munk A.C., Okinaka R.T., Parson-Quintana B.,
RA   Reilly L.P., Richardson P., Robinson D.L., Rubin E., Saunders E., Tapia R.,
RA   Tesmer J.G., Thayer N., Thompson L.S., Tice H., Ticknor L.O., Wills P.L.,
RA   Brettin T.S., Gilna P.;
RT   "Pathogenomic sequence analysis of Bacillus cereus and Bacillus
RT   thuringiensis isolates closely related to Bacillus anthracis.";
RL   J. Bacteriol. 188:3382-3390(2006).
CC   -!- FUNCTION: Multidrug efflux pump. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC       2.A.66.1) family. {ECO:0000305}.
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DR   EMBL; CP000001; AAU18980.1; -; Genomic_DNA.
DR   RefSeq; WP_000665387.1; NZ_CP009968.1.
DR   AlphaFoldDB; Q63DZ4; -.
DR   SMR; Q63DZ4; -.
DR   EnsemblBacteria; AAU18980; AAU18980; BCE33L1269.
DR   KEGG; bcz:BCE33L1269; -.
DR   PATRIC; fig|288681.22.peg.4287; -.
DR   OMA; TGNQKVG; -.
DR   Proteomes; UP000002612; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR002528; MATE_fam.
DR   Pfam; PF01554; MatE; 2.
DR   PIRSF; PIRSF006603; DinF; 1.
DR   TIGRFAMs; TIGR00797; matE; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell membrane; Ion transport; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..453
FT                   /note="Probable multidrug resistance protein NorM"
FT                   /id="PRO_0000164200"
FT   TRANSMEM        15..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        47..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        89..111
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        132..154
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        164..186
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        193..215
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        248..270
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        283..302
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        317..339
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        388..410
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        420..442
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   453 AA;  49766 MW;  3227B457DA1BF67D CRC64;
     MKETNSFSQK LKQFALLFFP IFVTQMSLFA MSFFDTTMSG HASPIDLAGV AIGTSIWIPV
     STGLTGILMA TTPIVAQLVG SKKKEDVPHV VIQAVYLAIC ASFVVILIGL FTVTPILNGM
     RLEEPVERIA AQFLSIIAIG IIPLFTYTVL RGFIDALGKT RTTMIITLLS LPINVILNYL
     LIFGNFGFPK LGGVGAAIAS TATYWCILII TVIIIHTKEP FASFNIFKHL YRPSLSSWKA
     FLKLGVPIGF AIFFETSIFA AVTLMMSNFS TTTIAAHQAA MNFASLLYMT PLSLAMAMTI
     AVGFEVGAKR YNNAKQYGFI GIGLALAFAL LYSILLYFFD NEIASIYTTD IQVHHLAKEF
     LIFAILFQIS DAIATPVQGA LRGYKDVNVA LIMTLIAYWV IGLPLGYILA TYTDWAAKGY
     WIGLIIGLAF GATFLLIRLF QVQRKYTTQN NRS