ID   NORM_BACHK              Reviewed;         453 AA.
AC   Q6HLG9;
DT   29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Probable multidrug resistance protein NorM;
DE   AltName: Full=Multidrug-efflux transporter;
GN   Name=norM; OrderedLocusNames=BT9727_1267;
OS   Bacillus thuringiensis subsp. konkukian (strain 97-27).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=281309;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=97-27;
RX   PubMed=16621833; DOI=10.1128/jb.188.9.3382-3390.2006;
RA   Han C.S., Xie G., Challacombe J.F., Altherr M.R., Bhotika S.S., Bruce D.,
RA   Campbell C.S., Campbell M.L., Chen J., Chertkov O., Cleland C.,
RA   Dimitrijevic M., Doggett N.A., Fawcett J.J., Glavina T., Goodwin L.A.,
RA   Hill K.K., Hitchcock P., Jackson P.J., Keim P., Kewalramani A.R.,
RA   Longmire J., Lucas S., Malfatti S., McMurry K., Meincke L.J., Misra M.,
RA   Moseman B.L., Mundt M., Munk A.C., Okinaka R.T., Parson-Quintana B.,
RA   Reilly L.P., Richardson P., Robinson D.L., Rubin E., Saunders E., Tapia R.,
RA   Tesmer J.G., Thayer N., Thompson L.S., Tice H., Ticknor L.O., Wills P.L.,
RA   Brettin T.S., Gilna P.;
RT   "Pathogenomic sequence analysis of Bacillus cereus and Bacillus
RT   thuringiensis isolates closely related to Bacillus anthracis.";
RL   J. Bacteriol. 188:3382-3390(2006).
CC   -!- FUNCTION: Multidrug efflux pump. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC       2.A.66.1) family. {ECO:0000305}.
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DR   EMBL; AE017355; AAT61948.1; -; Genomic_DNA.
DR   RefSeq; WP_000665388.1; NC_005957.1.
DR   RefSeq; YP_035602.1; NC_005957.1.
DR   AlphaFoldDB; Q6HLG9; -.
DR   SMR; Q6HLG9; -.
DR   EnsemblBacteria; AAT61948; AAT61948; BT9727_1267.
DR   KEGG; btk:BT9727_1267; -.
DR   PATRIC; fig|281309.8.peg.1335; -.
DR   HOGENOM; CLU_012893_6_0_9; -.
DR   OMA; TGNQKVG; -.
DR   Proteomes; UP000001301; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR002528; MATE_fam.
DR   Pfam; PF01554; MatE; 2.
DR   PIRSF; PIRSF006603; DinF; 1.
DR   TIGRFAMs; TIGR00797; matE; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell membrane; Ion transport; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..453
FT                   /note="Probable multidrug resistance protein NorM"
FT                   /id="PRO_0000164202"
FT   TRANSMEM        13..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        49..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        92..114
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        129..151
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        164..183
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        193..215
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        244..266
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        286..308
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        317..339
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        359..381
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        388..410
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        420..442
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   453 AA;  49768 MW;  8EDE48AD442AEC6D CRC64;
     MKETNSFSQK LKQFALLFFP IFVTQMSLFA MSFFDTTMSG HASPIDLAGV AIGTSIWIPV
     STGLTGILMA TTPIVAQLVG SKKKEDVPHV VIQAVYLAIC ASFVVILIGL FTVTPILNGM
     RLEEPVERIA AQFLSIIAIG IIPLFTYTVL RGFIDALGKT RTTMIITLLS LPINVVLNYV
     LIFGNFGFPK LGGVGAAIAS AATYWCILII TVMIIRTKEP FASFNIFKQL YRPSLSSWKE
     FLKLGVPIGF AIFFETSIFA AVTLMMSNFS TTTIAAHQAA MNFASLLYMT PLSLAMAMTI
     AVGFEVGAKR YNNAKQYGFI GIGLALAFAL LYSILLYFFD DEIASIYTTD IQVHHLAKEF
     LIFAILFQIS DAIATPVQGA LRGYKDVNVA LIMTLIAYWV IGLPLGYILA TYTDWAAKGY
     WIGLIIGLAF GATFLLIRLF QVQRKYTTQN SRS