ID   NORM_BORPA              Reviewed;         460 AA.
AC   Q7WAK9;
DT   29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Probable multidrug resistance protein NorM;
DE   AltName: Full=Multidrug-efflux transporter;
GN   Name=norM; OrderedLocusNames=BPP1367;
OS   Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Alcaligenaceae; Bordetella.
OX   NCBI_TaxID=257311;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=12822 / ATCC BAA-587 / NCTC 13253;
RX   PubMed=12910271; DOI=10.1038/ng1227;
RA   Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R.,
RA   Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L.,
RA   Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A.,
RA   Achtman M., Atkin R., Baker S., Basham D., Bason N., Cherevach I.,
RA   Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T.,
RA   Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S.,
RA   Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E.,
RA   Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M.,
RA   Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S.,
RA   Barrell B.G., Maskell D.J.;
RT   "Comparative analysis of the genome sequences of Bordetella pertussis,
RT   Bordetella parapertussis and Bordetella bronchiseptica.";
RL   Nat. Genet. 35:32-40(2003).
CC   -!- FUNCTION: Multidrug efflux pump. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC       2.A.66.1) family. {ECO:0000305}.
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DR   EMBL; BX640427; CAE36669.1; -; Genomic_DNA.
DR   RefSeq; WP_010928000.1; NC_002928.3.
DR   AlphaFoldDB; Q7WAK9; -.
DR   SMR; Q7WAK9; -.
DR   EnsemblBacteria; CAE36669; CAE36669; BPP1367.
DR   KEGG; bpa:BPP1367; -.
DR   HOGENOM; CLU_012893_6_3_4; -.
DR   OMA; AAWFELF; -.
DR   Proteomes; UP000001421; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR002528; MATE_fam.
DR   Pfam; PF01554; MatE; 2.
DR   PIRSF; PIRSF006603; DinF; 1.
DR   TIGRFAMs; TIGR00797; matE; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell inner membrane; Cell membrane; Ion transport; Membrane;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..460
FT                   /note="Probable multidrug resistance protein NorM"
FT                   /id="PRO_0000164206"
FT   TRANSMEM        20..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        57..79
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        99..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        136..158
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        165..187
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        197..219
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        250..272
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        282..304
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        325..347
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        362..379
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        400..422
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        427..449
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   460 AA;  48827 MW;  912DB5DCE124E57E CRC64;
     MPRSTARAAW KRELAATLAL GLPLVLTNLA QMAMTVTDVI FIGRLGSQAL AASALGANLF
     TAIEFFGLGL VAATAPMVAH ALGRRGNTVR DVRRTVRQGL WTAVIYSVPG CLLLWHGEAI
     LLAIDQPPEL AAQAGAYLRA LMWAMPPFLG FLVLRSFVTA LQRPRSAFLI ALAAIVLNVF
     GNWVLVFGNL GAPALGLVGA GLASALATLG LFLGMVGVVC LDRRFRRYHL FGDVWQPDWQ
     RLAEFWKLGL PIGAATAFEV TIFNAAAFLM GWLGEPELAA HAIAIQIASV TFMIPYGIAQ
     AATVRVGHAY GARQPDQVAR AGWCAFSLGI GSMAIAAALM LLAPGLLVSA FLDIGDPANA
     QVLRLATAYL AVAALFQIVD GAQVLGAGML RGLHDTRVPM LYAALGYWGV GLPSGAALAF
     WAGWRGVGVW SGLAIGLALV AVLMMQRWLR RDRVGLLRRA