ID   NORM_BRADU              Reviewed;         466 AA.
AC   Q89W72;
DT   29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Probable multidrug resistance protein NorM;
DE   AltName: Full=Multidrug-efflux transporter;
GN   Name=norM; OrderedLocusNames=bll0821;
OS   Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 /
OS   NBRC 14792 / USDA 110).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bradyrhizobiaceae; Bradyrhizobium.
OX   NCBI_TaxID=224911;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110;
RX   PubMed=12597275; DOI=10.1093/dnares/9.6.189;
RA   Kaneko T., Nakamura Y., Sato S., Minamisawa K., Uchiumi T., Sasamoto S.,
RA   Watanabe A., Idesawa K., Iriguchi M., Kawashima K., Kohara M.,
RA   Matsumoto M., Shimpo S., Tsuruoka H., Wada T., Yamada M., Tabata S.;
RT   "Complete genomic sequence of nitrogen-fixing symbiotic bacterium
RT   Bradyrhizobium japonicum USDA110.";
RL   DNA Res. 9:189-197(2002).
CC   -!- FUNCTION: Multidrug efflux pump. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC       2.A.66.1) family. {ECO:0000305}.
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DR   EMBL; BA000040; BAC46086.1; -; Genomic_DNA.
DR   RefSeq; NP_767461.1; NC_004463.1.
DR   AlphaFoldDB; Q89W72; -.
DR   SMR; Q89W72; -.
DR   STRING; 224911.27349070; -.
DR   EnsemblBacteria; BAC46086; BAC46086; BAC46086.
DR   KEGG; bja:bll0821; -.
DR   PATRIC; fig|224911.5.peg.844; -.
DR   eggNOG; COG0534; Bacteria.
DR   HOGENOM; CLU_012893_6_3_5; -.
DR   InParanoid; Q89W72; -.
DR   OMA; TGNQKVG; -.
DR   PhylomeDB; Q89W72; -.
DR   Proteomes; UP000002526; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0046677; P:response to antibiotic; IBA:GO_Central.
DR   InterPro; IPR002528; MATE_fam.
DR   Pfam; PF01554; MatE; 2.
DR   PIRSF; PIRSF006603; DinF; 1.
DR   TIGRFAMs; TIGR00797; matE; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell inner membrane; Cell membrane; Ion transport; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..466
FT                   /note="Probable multidrug resistance protein NorM"
FT                   /id="PRO_0000164207"
FT   TRANSMEM        68..90
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        110..132
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        142..164
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        177..199
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        209..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        251..273
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        288..310
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        331..353
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        368..387
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        407..429
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        433..455
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   466 AA;  49217 MW;  BBD66F41E70E694A CRC64;
     MTMLDTVQHH SQPQSGVPQN HLADEFVETL RLAVPMMLTQ LGQIAMITTD LALIGRLGED
     AVAAAALAHT VYFVSFTFGL GLMAAVSPLV AQAFGAGDVR RIRRALRVGL WVALLISLPM
     MASPLYGEHI LIALGQVPQS AALAQRYLNG LAWGIAPALG FIALRGMMSA VNRPQPPLWI
     TVAAIPVNAA LVYVLIHGLF GLPELGLFGA GLATTLVNLG TFLAVLAIAA WRKPFSDYRP
     LAHLWRIDWP LVRQLIALGA PISSSLLLEY GLFSSAALLM GLISTTALAA HQIALQVTAV
     LFMVPLGIGM AATVRVGHAF GRNDPAAVRR AGLVAAVLGV ALVSALTVAI ILGRYELGRL
     FFGGSEASAA TVELTATLLL VGATFFIADG LQTIMGGALR GINDTRMTLA FAAIGYWCVA
     FPVAWVLAFH TGLGAVGVWI GFSIGTFVYA GLLVLRFRML ARRLVG