ID   NORM_BRUME              Reviewed;         471 AA.
AC   Q8YFD7;
DT   29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Probable multidrug resistance protein NorM;
DE   AltName: Full=Multidrug-efflux transporter;
GN   Name=norM; OrderedLocusNames=BMEI1585;
OS   Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=224914;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=16M / ATCC 23456 / NCTC 10094;
RX   PubMed=11756688; DOI=10.1073/pnas.221575398;
RA   DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T.,
RA   Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G.,
RA   Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E.,
RA   Selkov E., Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J.,
RA   Haselkorn R., Kyrpides N.C., Overbeek R.;
RT   "The genome sequence of the facultative intracellular pathogen Brucella
RT   melitensis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002).
CC   -!- FUNCTION: Multidrug efflux pump. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC       2.A.66.1) family. {ECO:0000305}.
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DR   EMBL; AE008917; AAL52766.1; -; Genomic_DNA.
DR   PIR; AC3450; AC3450.
DR   RefSeq; WP_004682927.1; NZ_GG703778.1.
DR   AlphaFoldDB; Q8YFD7; -.
DR   SMR; Q8YFD7; -.
DR   STRING; 224914.BMEI1585; -.
DR   EnsemblBacteria; AAL52766; AAL52766; BMEI1585.
DR   GeneID; 45051463; -.
DR   GeneID; 55590109; -.
DR   KEGG; bme:BMEI1585; -.
DR   PATRIC; fig|224914.52.peg.2005; -.
DR   eggNOG; COG0534; Bacteria.
DR   OMA; TGNQKVG; -.
DR   PhylomeDB; Q8YFD7; -.
DR   Proteomes; UP000000419; Chromosome I.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR002528; MATE_fam.
DR   Pfam; PF01554; MatE; 2.
DR   PIRSF; PIRSF006603; DinF; 1.
DR   TIGRFAMs; TIGR00797; matE; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell inner membrane; Cell membrane; Ion transport; Membrane;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..471
FT                   /note="Probable multidrug resistance protein NorM"
FT                   /id="PRO_0000164208"
FT   TRANSMEM        30..52
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        67..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        110..132
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        147..169
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        176..198
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        208..230
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        255..277
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        287..309
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        330..352
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        372..389
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        410..432
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        436..458
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   471 AA;  51685 MW;  C2BFEC2A83B1ACA7 CRC64;
     MDGTFDAGFR EPTISKANRW GREMVVALKL GWPLIFTNLS QAALTATDVI FIGRLGADTL
     ASALLATSFY HTLMIFSMGL VSAVMPMIAI ALGKNRHSVR DVRRTVRQGF WSAIMIVIPL
     WVVLWHCEEI FLFLGQRPDI AARSTDFMHT LQWALLPYLF YIVLRSFFAA MEKPMWTLLV
     AALAIGFNAL AGWTLIFGHF GFAPMGLHGA GMATTASSTM MFLGLAFITL RHPRFRRYHL
     FGRFWRPDWP RLIELWRIGL PMALTFVFET SIFYAAVVMM GRIGPTAMAA HAVAIQIASL
     SFMVPLGFGQ VATVRVGRAY GRGDPKAIAY AGWSAYALGV GFMALMGILM VLMPRVFIGI
     FLNLNDPQNL PVMELAVTFL ALAALFQIVD GAQAVAAGML RGLRDTRIPM LLALFGYWGV
     GLPLGAVLAF QFGMGGVGIW LGLAAGLGMV AVLMTIRWRR HLAHVSAVAA A