NORM_BUCBP
ID NORM_BUCBP Reviewed; 451 AA.
AC Q89AX2;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Probable multidrug resistance protein NorM;
DE AltName: Full=Multidrug-efflux transporter;
GN Name=norM; OrderedLocusNames=bbp_106;
OS Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Erwiniaceae; Buchnera.
OX NCBI_TaxID=224915;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bp;
RX PubMed=12522265; DOI=10.1073/pnas.0235981100;
RA van Ham R.C.H.J., Kamerbeek J., Palacios C., Rausell C., Abascal F.,
RA Bastolla U., Fernandez J.M., Jimenez L., Postigo M., Silva F.J.,
RA Tamames J., Viguera E., Latorre A., Valencia A., Moran F., Moya A.;
RT "Reductive genome evolution in Buchnera aphidicola.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:581-586(2003).
CC -!- FUNCTION: Multidrug efflux pump. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC 2.A.66.1) family. {ECO:0000305}.
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DR EMBL; AE016826; AAO26840.1; -; Genomic_DNA.
DR RefSeq; WP_011091241.1; NC_004545.1.
DR AlphaFoldDB; Q89AX2; -.
DR SMR; Q89AX2; -.
DR STRING; 224915.bbp_106; -.
DR EnsemblBacteria; AAO26840; AAO26840; bbp_106.
DR GeneID; 56470650; -.
DR KEGG; bab:bbp_106; -.
DR eggNOG; COG0534; Bacteria.
DR HOGENOM; CLU_012893_6_0_6; -.
DR OMA; TGNQKVG; -.
DR OrthoDB; 1415498at2; -.
DR Proteomes; UP000000601; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR002528; MATE_fam.
DR Pfam; PF01554; MatE; 2.
DR TIGRFAMs; TIGR00797; matE; 1.
PE 3: Inferred from homology;
KW Antiport; Cell membrane; Ion transport; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..451
FT /note="Probable multidrug resistance protein NorM"
FT /id="PRO_0000164210"
FT TRANSMEM 44..66
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 92..109
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 130..147
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 162..179
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 186..208
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 247..269
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 282..304
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 319..341
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 391..413
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 423..445
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 451 AA; 51162 MW; 399AE89242445ADE CRC64;
MKKHLHEIKM LLKITIPIFL AQISQTSMSL INSIMIGHLK ENNIAAISVG ISIWSPIILF
GHGLLLSLVP TVSRIHGSGK INKIPEQINN AYWLATLISL VIMIVLWNSD VIIHTISQVN
PIIEQESIKY IRILLWSTPG YLYFQVIQNQ CEGLLKPKPA MVIGLIGLLF NIVVSYTLIS
EKFHCFNYGS TGCGISAIIV YWFMFIAMKK ITKNDILINY NIKNKNISNL EMYLPNYKII
WNLFKMGFPI ALSLFCEITL FTLITLLIAS METFQIIAHQ IALNISSTIF ILPLSIATAA
SIRLGFYLGK KSFSKISTII LSSQIIGLII STTISTFIIL FHYQIITLYT KNANIIKLTK
QMLFITASYQ IFDFFQIIGN GILRSYKDTN IIFIITCTSY WIVGFPFGYF LALTNYIVPH
MGAIGFWYGI LIALITSSIM ILFRIYILQK K
