ID   NORM_BURPS              Reviewed;         468 AA.
AC   Q63S57;
DT   29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Probable multidrug resistance protein NorM;
DE   AltName: Full=Multidrug-efflux transporter;
GN   Name=norM; OrderedLocusNames=BPSL2468;
OS   Burkholderia pseudomallei (strain K96243).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; pseudomallei group.
OX   NCBI_TaxID=272560;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K96243;
RX   PubMed=15377794; DOI=10.1073/pnas.0403302101;
RA   Holden M.T.G., Titball R.W., Peacock S.J., Cerdeno-Tarraga A.-M.,
RA   Atkins T., Crossman L.C., Pitt T., Churcher C., Mungall K.L., Bentley S.D.,
RA   Sebaihia M., Thomson N.R., Bason N., Beacham I.R., Brooks K., Brown K.A.,
RA   Brown N.F., Challis G.L., Cherevach I., Chillingworth T., Cronin A.,
RA   Crossett B., Davis P., DeShazer D., Feltwell T., Fraser A., Hance Z.,
RA   Hauser H., Holroyd S., Jagels K., Keith K.E., Maddison M., Moule S.,
RA   Price C., Quail M.A., Rabbinowitsch E., Rutherford K., Sanders M.,
RA   Simmonds M., Songsivilai S., Stevens K., Tumapa S., Vesaratchavest M.,
RA   Whitehead S., Yeats C., Barrell B.G., Oyston P.C.F., Parkhill J.;
RT   "Genomic plasticity of the causative agent of melioidosis, Burkholderia
RT   pseudomallei.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:14240-14245(2004).
CC   -!- FUNCTION: Multidrug efflux pump. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC       2.A.66.1) family. {ECO:0000305}.
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DR   EMBL; BX571965; CAH36471.1; -; Genomic_DNA.
DR   RefSeq; WP_009938335.1; NZ_CP009538.1.
DR   RefSeq; YP_109060.1; NC_006350.1.
DR   AlphaFoldDB; Q63S57; -.
DR   SMR; Q63S57; -.
DR   STRING; 272560.BPSL2468; -.
DR   EnsemblBacteria; CAH36471; CAH36471; BPSL2468.
DR   KEGG; bps:BPSL2468; -.
DR   PATRIC; fig|272560.51.peg.2921; -.
DR   eggNOG; COG0534; Bacteria.
DR   OMA; AAWFELF; -.
DR   Proteomes; UP000000605; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR002528; MATE_fam.
DR   Pfam; PF01554; MatE; 2.
DR   PIRSF; PIRSF006603; DinF; 1.
DR   TIGRFAMs; TIGR00797; matE; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell inner membrane; Cell membrane; Ion transport; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..468
FT                   /note="Probable multidrug resistance protein NorM"
FT                   /id="PRO_0000164212"
FT   TRANSMEM        57..79
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..122
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        142..164
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        173..195
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        205..227
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        248..270
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        280..302
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        323..345
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        360..382
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        401..423
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        433..452
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   468 AA;  48159 MW;  1894A9C291A0599A CRC64;
     MSPTGFTRAA AAPPPTLSRH AADTARLAAP LAIAQLSQMA MSVTDTVLLG SLGPDALAAG
     GLGANLSFVV VTLLQGVLTS VSVSVAHARG AMAEDRVPHI YWTGFALSLL LAVPAFALLS
     FAQPLLLAFG EPAALARNVG EYAAVLRFAA PGSLIGVGLM RSFLPAIGAA KRLLWVSLAG
     VGVNAFLNYG LIHGAFGLPR LGFLGSATAT TITIWLTAIT LVALLHGRST FRHFVAATRP
     RLPLMGELFG IGWPVAITYG VESTLFLATG LTVGVLGESS LAAHQIALNV ASVAFMVPLA
     IGQAANVRVG YWAGAGAPVA ARHAGFVALG LGVAFMSLSG LVLIVAPHAI VGLYLKLDDP
     ANARTVVLAT SLLGIAAVFQ IVDGMQTVGS GCLRGLKDTR VPMLAAMLGY WGIGFPTGYW
     FAFHAGLGAR GLWWGLAAGL ASVAMLMTWR FHRKSAALGV RADARGQA