ID   NORM_BURVI              Reviewed;         462 AA.
AC   Q9F5N7;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Multidrug resistance protein NorM;
DE   AltName: Full=Multidrug-efflux transporter;
GN   Name=norM;
OS   Burkholderia vietnamiensis.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX   NCBI_TaxID=60552;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=CEP040;
RX   PubMed=12399047; DOI=10.1111/j.1574-6968.2002.tb11403.x;
RA   Fehlner-Gardiner C.C., Valvano M.A.;
RT   "Cloning and characterization of the Burkholderia vietnamiensis norM gene
RT   encoding a multi-drug efflux protein.";
RL   FEMS Microbiol. Lett. 215:279-283(2002).
CC   -!- FUNCTION: Multidrug efflux pump. Confers probably resistance to the
CC       cationic peptide polymyxin B (PMB). {ECO:0000269|PubMed:12399047}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC       2.A.66.1) family. {ECO:0000305}.
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DR   EMBL; AF312031; AAG27731.1; -; Genomic_DNA.
DR   RefSeq; WP_011883895.1; NZ_UZVT01000001.1.
DR   AlphaFoldDB; Q9F5N7; -.
DR   SMR; Q9F5N7; -.
DR   TCDB; 2.A.66.1.9; the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily.
DR   PRIDE; Q9F5N7; -.
DR   OMA; AAWFELF; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR002528; MATE_fam.
DR   Pfam; PF01554; MatE; 2.
DR   PIRSF; PIRSF006603; DinF; 1.
DR   TIGRFAMs; TIGR00797; matE; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance; Antiport; Cell inner membrane; Cell membrane;
KW   Ion transport; Membrane; Sodium; Sodium transport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..462
FT                   /note="Multidrug resistance protein NorM"
FT                   /id="PRO_0000164213"
FT   TRANSMEM        56..76
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        99..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        147..167
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        172..192
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        202..222
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        247..267
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        280..300
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        325..345
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        361..381
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        402..422
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        430..450
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   462 AA;  47860 MW;  0CAFB2EC20652D11 CRC64;
     MSHSGLTRTA AAPPSLSRHA VDTARLAAPL AIAQLSQMAM SVTDTVLLGS LGPDSLAAGG
     LGANFFFVIV TVLQGVLSSV SVSVAHARGA QAEHRVPHIY WTGFVLSVLL AIPAVVALSL
     SEPLLLMFHE PPTLAQHVGE YTGILRFAAL GSLIGVGLMR AFLPAIGAAR RLLWVSIGGI
     GVNAVLNYGL IHGAYGLPRL GFLGSAVATT ITIWLTAFAL IWLLHGRARF RHFVSAARPK
     LPMMGELIGI GWPVAITYGV ESTLFLATGL TVGVLGATAL AAHQIALNVA SVAFMVPLAI
     GQAANVRVGY WIGAGDPVAA RHAGFVALGL GVAFMSLSGL VLILAPHAIV GLYLHLDDPA
     NAATVSLAAS LLGIAAVFQI VDGMQTVGSG ALRGLRDTRI PMLAATFGYW GIGFPTGYWL
     AFHAGLGARG LWWGLAAGLA SVAVLMAWRF HLKTSSLIAA PR