ID   NORM_CAUVC              Reviewed;         471 AA.
AC   P58163;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=Probable multidrug resistance protein NorM;
DE   AltName: Full=Multidrug-efflux transporter;
GN   Name=norM; OrderedLocusNames=CC_2020;
OS   Caulobacter vibrioides (strain ATCC 19089 / CB15) (Caulobacter crescentus).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC   Caulobacteraceae; Caulobacter.
OX   NCBI_TaxID=190650;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 19089 / CB15;
RX   PubMed=11259647; DOI=10.1073/pnas.061029298;
RA   Nierman W.C., Feldblyum T.V., Laub M.T., Paulsen I.T., Nelson K.E.,
RA   Eisen J.A., Heidelberg J.F., Alley M.R.K., Ohta N., Maddock J.R.,
RA   Potocka I., Nelson W.C., Newton A., Stephens C., Phadke N.D., Ely B.,
RA   DeBoy R.T., Dodson R.J., Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F.,
RA   Smit J., Craven M.B., Khouri H.M., Shetty J., Berry K.J., Utterback T.R.,
RA   Tran K., Wolf A.M., Vamathevan J.J., Ermolaeva M.D., White O.,
RA   Salzberg S.L., Venter J.C., Shapiro L., Fraser C.M.;
RT   "Complete genome sequence of Caulobacter crescentus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:4136-4141(2001).
CC   -!- FUNCTION: Multidrug efflux pump. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC       2.A.66.1) family. {ECO:0000305}.
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DR   EMBL; AE005673; AAK23995.1; -; Genomic_DNA.
DR   PIR; G87499; G87499.
DR   RefSeq; NP_420827.1; NC_002696.2.
DR   RefSeq; WP_010919886.1; NC_002696.2.
DR   AlphaFoldDB; P58163; -.
DR   SMR; P58163; -.
DR   STRING; 190650.CC_2020; -.
DR   TCDB; 2.A.66.1.27; the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily.
DR   EnsemblBacteria; AAK23995; AAK23995; CC_2020.
DR   KEGG; ccr:CC_2020; -.
DR   PATRIC; fig|190650.5.peg.2040; -.
DR   eggNOG; COG0534; Bacteria.
DR   HOGENOM; CLU_012893_6_4_5; -.
DR   OMA; TGNQKVG; -.
DR   BioCyc; CAULO:CC2020-MON; -.
DR   Proteomes; UP000001816; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR002528; MATE_fam.
DR   Pfam; PF01554; MatE; 2.
DR   PIRSF; PIRSF006603; DinF; 1.
DR   TIGRFAMs; TIGR00797; matE; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell inner membrane; Cell membrane; Ion transport; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..471
FT                   /note="Probable multidrug resistance protein NorM"
FT                   /id="PRO_0000164214"
FT   TRANSMEM        38..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        114..134
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        152..172
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        197..217
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        266..286
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        289..309
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        334..354
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        370..390
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        409..429
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        434..454
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   471 AA;  49531 MW;  71F243BED62BDDFD CRC64;
     MTVVTTMPRD AAGTALLPER PRGPIMTDLI ELLRLAGPVV LSRLGIMVMG LTDAIVVGHF
     SAQQLGYHAM AWAPSSVFVT ATVGLLVGVQ VMTARAMGAG NPHETGAVLR RGLVYAGWLG
     FGSMALLALF GPMFLQAMGL KDGLAEGATL PLIVFSLSLP VYAISVVLTF WLEGLSRPGP
     GAAMMWLANV VNLGANLLLV PGVLGPPALG AVGGAWATFI ARTALALALA IFVIRMKEAR
     ELGVFDKPAR DRPAEIEQRR IGYGAGASNF FEVSAFAGMN LICGWISAVA VAAYTVVLNV
     SAIIFMVPLG VASATAVMVG RAYGARDPAG MTRAGWIAFA VIGVIGVLFG LLLYPTKHWV
     ALAYTTDPAA LALILPALVL ACLFFAPDAV QVVAAQALRA RGEVWVPTIT HLISYALVMG
     PLAWWLAIPK GMGLNGVLVS IIVTSFLAAG FLLMRFRMLD WRDRKAAQEA A