NORM_CHRVO
ID NORM_CHRVO Reviewed; 465 AA.
AC Q7NXN3;
DT 29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2003, sequence version 1.
DT 25-MAY-2022, entry version 110.
DE RecName: Full=Probable multidrug resistance protein NorM;
DE AltName: Full=Multidrug-efflux transporter;
GN Name=norM; OrderedLocusNames=CV_1593;
OS Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC
OS 12614 / NCIMB 9131 / NCTC 9757).
OC Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales;
OC Chromobacteriaceae; Chromobacterium.
OX NCBI_TaxID=243365;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC
RC 9757;
RX PubMed=14500782; DOI=10.1073/pnas.1832124100;
RA Vasconcelos A.T.R., de Almeida D.F., Hungria M., Guimaraes C.T.,
RA Antonio R.V., Almeida F.C., de Almeida L.G.P., de Almeida R.,
RA Alves-Gomes J.A., Andrade E.M., Araripe J., de Araujo M.F.F.,
RA Astolfi-Filho S., Azevedo V., Baptista A.J., Bataus L.A.M., Batista J.S.,
RA Belo A., van den Berg C., Bogo M., Bonatto S., Bordignon J., Brigido M.M.,
RA Brito C.A., Brocchi M., Burity H.A., Camargo A.A., Cardoso D.D.P.,
RA Carneiro N.P., Carraro D.M., Carvalho C.M.B., Cascardo J.C.M., Cavada B.S.,
RA Chueire L.M.O., Creczynski-Pasa T.B., Cunha-Junior N.C., Fagundes N.,
RA Falcao C.L., Fantinatti F., Farias I.P., Felipe M.S.S., Ferrari L.P.,
RA Ferro J.A., Ferro M.I.T., Franco G.R., Freitas N.S.A., Furlan L.R.,
RA Gazzinelli R.T., Gomes E.A., Goncalves P.R., Grangeiro T.B.,
RA Grattapaglia D., Grisard E.C., Hanna E.S., Jardim S.N., Laurino J.,
RA Leoi L.C.T., Lima L.F.A., Loureiro M.F., Lyra M.C.C.P., Madeira H.M.F.,
RA Manfio G.P., Maranhao A.Q., Martins W.S., di Mauro S.M.Z.,
RA de Medeiros S.R.B., Meissner R.V., Moreira M.A.M., Nascimento F.F.,
RA Nicolas M.F., Oliveira J.G., Oliveira S.C., Paixao R.F.C., Parente J.A.,
RA Pedrosa F.O., Pena S.D.J., Pereira J.O., Pereira M., Pinto L.S.R.C.,
RA Pinto L.S., Porto J.I.R., Potrich D.P., Ramalho-Neto C.E., Reis A.M.M.,
RA Rigo L.U., Rondinelli E., Santos E.B.P., Santos F.R., Schneider M.P.C.,
RA Seuanez H.N., Silva A.M.R., da Silva A.L.C., Silva D.W., Silva R.,
RA Simoes I.C., Simon D., Soares C.M.A., Soares R.B.A., Souza E.M.,
RA Souza K.R.L., Souza R.C., Steffens M.B.R., Steindel M., Teixeira S.R.,
RA Urmenyi T., Vettore A., Wassem R., Zaha A., Simpson A.J.G.;
RT "The complete genome sequence of Chromobacterium violaceum reveals
RT remarkable and exploitable bacterial adaptability.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:11660-11665(2003).
CC -!- FUNCTION: Multidrug efflux pump. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC 2.A.66.1) family. {ECO:0000305}.
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DR EMBL; AE016825; AAQ59269.1; -; Genomic_DNA.
DR RefSeq; WP_011135145.1; NC_005085.1.
DR AlphaFoldDB; Q7NXN3; -.
DR SMR; Q7NXN3; -.
DR STRING; 243365.CV_1593; -.
DR EnsemblBacteria; AAQ59269; AAQ59269; CV_1593.
DR KEGG; cvi:CV_1593; -.
DR eggNOG; COG0534; Bacteria.
DR HOGENOM; CLU_012893_6_0_4; -.
DR OMA; TGNQKVG; -.
DR OrthoDB; 1415498at2; -.
DR Proteomes; UP000001424; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR002528; MATE_fam.
DR Pfam; PF01554; MatE; 2.
DR PIRSF; PIRSF006603; DinF; 1.
DR TIGRFAMs; TIGR00797; matE; 1.
PE 3: Inferred from homology;
KW Antiport; Cell inner membrane; Cell membrane; Ion transport; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..465
FT /note="Probable multidrug resistance protein NorM"
FT /id="PRO_0000164215"
FT TRANSMEM 21..43
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..80
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..122
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 137..156
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 169..191
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 201..223
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 250..272
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 287..309
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 322..344
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 359..376
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 395..417
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 427..449
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 465 AA; 50020 MW; 00C06A5CB2F80787 CRC64;
MLFELNRASR AEILAEARQI AGLALPMMVA QIAQVATSFV DTVMAGRVGT DDLAAVSLGA
SVFITVYVTL MGVVAALNPI LSHHLGSRDR RAFSRDAAQG LWFGLMLGAL GAGLMLLLEA
PLRHWLHLPP DVTDKVMLFI TGAAIGMPAA MAHRALHAYA SSLGHPKAIM VVSLLALALN
IPLNYILIHG LFGMPRMGGA GCGWATGIVF WFNCLALLTY VSWHRHFRDS RILAGLAAPD
WRRFLAFLKL GVPIGLSFFV EVSLFSFIAL LIAELGTVVV ATHQSVLNFS SLIYMLPQSV
ATALSVRVGH HAGAGDYRAA RFISGVGMLM GLAMAGGAMA LVLLLREPIM WMYSADPRVI
AMGTTLLLFA AVYQLTDAAQ TIASGALRGY KLTAVPMLIH ITSFWVAGLG LGMLLGLTDW
IVPRMGIYGF WTALVISLTV AGLLLTYYLA RASRKRLHRD QGILL
