ID   NORM_DEIRA              Reviewed;         451 AA.
AC   Q9RY44;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 122.
DE   RecName: Full=Probable multidrug resistance protein NorM;
DE   AltName: Full=Multidrug-efflux transporter;
GN   Name=norM; OrderedLocusNames=DR_0107;
OS   Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG
OS   4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422).
OC   Bacteria; Deinococcus-Thermus; Deinococci; Deinococcales; Deinococcaceae;
OC   Deinococcus.
OX   NCBI_TaxID=243230;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB
RC   9279 / R1 / VKM B-1422;
RX   PubMed=10567266; DOI=10.1126/science.286.5444.1571;
RA   White O., Eisen J.A., Heidelberg J.F., Hickey E.K., Peterson J.D.,
RA   Dodson R.J., Haft D.H., Gwinn M.L., Nelson W.C., Richardson D.L.,
RA   Moffat K.S., Qin H., Jiang L., Pamphile W., Crosby M., Shen M.,
RA   Vamathevan J.J., Lam P., McDonald L.A., Utterback T.R., Zalewski C.,
RA   Makarova K.S., Aravind L., Daly M.J., Minton K.W., Fleischmann R.D.,
RA   Ketchum K.A., Nelson K.E., Salzberg S.L., Smith H.O., Venter J.C.,
RA   Fraser C.M.;
RT   "Genome sequence of the radioresistant bacterium Deinococcus radiodurans
RT   R1.";
RL   Science 286:1571-1577(1999).
CC   -!- FUNCTION: Multidrug efflux pump. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC       2.A.66.1) family. {ECO:0000305}.
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DR   EMBL; AE000513; AAF09695.1; -; Genomic_DNA.
DR   PIR; H75559; H75559.
DR   RefSeq; NP_293833.1; NC_001263.1.
DR   RefSeq; WP_010886755.1; NZ_CP015081.1.
DR   AlphaFoldDB; Q9RY44; -.
DR   SMR; Q9RY44; -.
DR   STRING; 243230.DR_0107; -.
DR   EnsemblBacteria; AAF09695; AAF09695; DR_0107.
DR   KEGG; dra:DR_0107; -.
DR   PATRIC; fig|243230.17.peg.272; -.
DR   eggNOG; COG0534; Bacteria.
DR   HOGENOM; CLU_012893_6_3_0; -.
DR   InParanoid; Q9RY44; -.
DR   OMA; TGNQKVG; -.
DR   OrthoDB; 1415498at2; -.
DR   Proteomes; UP000002524; Chromosome I.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0046677; P:response to antibiotic; IBA:GO_Central.
DR   InterPro; IPR002528; MATE_fam.
DR   Pfam; PF01554; MatE; 2.
DR   PIRSF; PIRSF006603; DinF; 1.
DR   TIGRFAMs; TIGR00797; matE; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell membrane; Ion transport; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..451
FT                   /note="Probable multidrug resistance protein NorM"
FT                   /id="PRO_0000164216"
FT   TRANSMEM        23..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        53..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        132..152
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        169..189
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        194..214
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        243..263
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        277..297
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        316..336
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        355..375
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        391..411
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        422..442
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   451 AA;  45984 MW;  DD5985103CE348FA CRC64;
     MTTLPAPTIS TTAELRALLR LAGPVVVSQF AANALALIAT AVIGRLGERE LAAAAYANAA
     YYLVFIMVVG VMLSVAPRVA QAHGAGDARG VARALGGGLR LALLLSAVML PLMWALSFVL
     PNFAPAGVSR DLVAAYLRVY SLGMLPNLAF IALRGTLEGT GKPGAVTGVA LTGVVWALLV
     APALAFGWGP LPRLGLAGAA GASASAAWIM AALLWPLARR RVAYAGPLGP LGDEVRALFR
     LGWPIGLTLG AEGGMFSVTT LLMARFGPEV LAAHNVTMQT ITAFFMVPLG IASATGVRVG
     TEAGAGRLAQ ARRAGLVGLG LSSAVMLTFA VIELAAPRTV FSVFVNVNDP ANAGLIAAAT
     GFLSIAALFQ LMDGLQVTAN GALRGLQDTR VPLLVSLVAY WVVGLGLGSV LSSVAGLGAR
     GLWFGLTAGL TLAGLSLVGR FLYRTRAGRA A