ID   NORM_GEOKA              Reviewed;         455 AA.
AC   Q5KZL2;
DT   29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Probable multidrug resistance protein NorM;
DE   AltName: Full=Multidrug-efflux transporter;
GN   Name=norM; OrderedLocusNames=GK1589;
OS   Geobacillus kaustophilus (strain HTA426).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Geobacillus;
OC   Geobacillus thermoleovorans group.
OX   NCBI_TaxID=235909;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HTA426;
RX   PubMed=15576355; DOI=10.1093/nar/gkh970;
RA   Takami H., Takaki Y., Chee G.-J., Nishi S., Shimamura S., Suzuki H.,
RA   Matsui S., Uchiyama I.;
RT   "Thermoadaptation trait revealed by the genome sequence of thermophilic
RT   Geobacillus kaustophilus.";
RL   Nucleic Acids Res. 32:6292-6303(2004).
CC   -!- FUNCTION: Multidrug efflux pump. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC       2.A.66.1) family. {ECO:0000305}.
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DR   EMBL; BA000043; BAD75874.1; -; Genomic_DNA.
DR   RefSeq; WP_011231084.1; NC_006510.1.
DR   AlphaFoldDB; Q5KZL2; -.
DR   SMR; Q5KZL2; -.
DR   STRING; 235909.GK1589; -.
DR   EnsemblBacteria; BAD75874; BAD75874; GK1589.
DR   KEGG; gka:GK1589; -.
DR   eggNOG; COG0534; Bacteria.
DR   HOGENOM; CLU_012893_6_0_9; -.
DR   OMA; TGNQKVG; -.
DR   Proteomes; UP000001172; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR002528; MATE_fam.
DR   Pfam; PF01554; MatE; 2.
DR   PIRSF; PIRSF006603; DinF; 1.
DR   TIGRFAMs; TIGR00797; matE; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell membrane; Ion transport; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..455
FT                   /note="Probable multidrug resistance protein NorM"
FT                   /id="PRO_0000164217"
FT   TRANSMEM        13..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        51..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        94..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        131..150
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        162..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        194..216
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        245..267
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        282..304
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        317..339
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        352..369
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        390..412
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        417..439
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   455 AA;  48766 MW;  15D13C211FD868A6 CRC64;
     MATTAPPNGK WRRLFALFLP IFVSQTGQYA MNFVDVAMSG HASAEDLAGV AIGSSLWVPV
     FTGAGGILLA LSPIVSHHFG AGRHDSITRA VAQALYLAVA LAVAIVLIGA AAVPFILKQM
     SLDENVRHIA FHYLRALSFG IIPLFLYSVL RYFIDALGQT KVTMWITLTA LPVNMLFNWL
     LIYGHGGFPR LGGIGTGYAT AITYAYCFAA AAFAALKFRR LAPYRVLVRF YRPSWAAWKE
     LLKTGVPIGS AIFFETSIFA AVTLLVGRFG AETVAAHQSA LNFASLLYMI PLSLSMALTI
     AVGVEAGANR YEAAKQYCLI GITLALAVAA AAALFLSAFR SHVARLYTND PTVAALTGKF
     LLYAIFFQVS DAIAAPIQGA LRGYKEVNAV FWSALLAYWG VGLPLGCALA LLTAAGAFGY
     WIGLIAGLAT GALFLSFRLR AVWRRHDSGR APCAF