ID   NORM_HAEDU              Reviewed;         463 AA.
AC   Q7VMB5;
DT   29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=Probable multidrug resistance protein NorM;
DE   AltName: Full=Multidrug-efflux transporter;
GN   Name=norM; OrderedLocusNames=HD_1075;
OS   Haemophilus ducreyi (strain 35000HP / ATCC 700724).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=233412;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=35000HP / ATCC 700724;
RA   Munson R.S. Jr., Ray W.C., Mahairas G., Sabo P., Mungur R., Johnson L.,
RA   Nguyen D., Wang J., Forst C., Hood L.;
RT   "The complete genome sequence of Haemophilus ducreyi.";
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Multidrug efflux pump. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC       2.A.66.1) family. {ECO:0000305}.
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DR   EMBL; AE017143; AAP95942.1; -; Genomic_DNA.
DR   RefSeq; WP_010944991.1; NC_002940.2.
DR   AlphaFoldDB; Q7VMB5; -.
DR   SMR; Q7VMB5; -.
DR   STRING; 233412.HD_1075; -.
DR   EnsemblBacteria; AAP95942; AAP95942; HD_1075.
DR   KEGG; hdu:HD_1075; -.
DR   eggNOG; COG0534; Bacteria.
DR   HOGENOM; CLU_012893_6_0_6; -.
DR   OMA; TGNQKVG; -.
DR   Proteomes; UP000001022; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR002528; MATE_fam.
DR   Pfam; PF01554; MatE; 2.
DR   PIRSF; PIRSF006603; DinF; 1.
DR   TIGRFAMs; TIGR00797; matE; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell inner membrane; Cell membrane; Ion transport; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..463
FT                   /note="Probable multidrug resistance protein NorM"
FT                   /id="PRO_0000164218"
FT   TRANSMEM        20..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        57..79
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        96..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        133..150
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        162..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        194..216
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        245..267
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        287..306
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        318..340
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        355..377
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        390..412
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        422..444
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   463 AA;  50965 MW;  A039D5A12398E185 CRC64;
     MNLQWQKYPE NASKLFKLTV PIFISQLSAS GMGLADIVMA GLVSDDDVSA IAVSNSIYFP
     LFLFVLGVLN AITPTVSYLN GANQRNLIAH QIRQGFWLVW AFVIPLIVVF LNSHWILDYM
     NTPAVFAQKS QDYLAIMAIG IVPALLTVNL RCMNDGLANP KPAMRITFIG LLCNIPLNYI
     FIFGKFGVPE MGAVGCGVAT AIVNWSMFLM MFHYCYTNKP QKDIGLFNKW FEMPSGKTLL
     KICKLGLPIG FATFTEVMLF STSALFLSPL GSQVVASHQT ALQTSSMLFM VPLSFGIATT
     IVLGRVLGQK LVEEAKIISY HALITGVIFA VIAAILIVLF NNIIPLAFTR DPVSIAIASH
     LLLFAAVYQI PDSLQVVANG ILRGYKHTKP VLYVTVFCYW GIGIPFGYVL ARTDWIVQPM
     AAAGFWLIFC VSLSLASGLL IYQIRKIQKI PAATLIAKLE RIK