ID   NORM_IDILO              Reviewed;         462 AA.
AC   Q5QWR6;
DT   29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=Probable multidrug resistance protein NorM;
DE   AltName: Full=Multidrug-efflux transporter;
GN   Name=norM; OrderedLocusNames=IL1842;
OS   Idiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Idiomarinaceae; Idiomarina.
OX   NCBI_TaxID=283942;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-735 / DSM 15497 / L2-TR;
RX   PubMed=15596722; DOI=10.1073/pnas.0407638102;
RA   Hou S., Saw J.H., Lee K.S., Freitas T.A., Belisle C., Kawarabayasi Y.,
RA   Donachie S.P., Pikina A., Galperin M.Y., Koonin E.V., Makarova K.S.,
RA   Omelchenko M.V., Sorokin A., Wolf Y.I., Li Q.X., Keum Y.S., Campbell S.,
RA   Denery J., Aizawa S., Shibata S., Malahoff A., Alam M.;
RT   "Genome sequence of the deep-sea gamma-proteobacterium Idiomarina
RT   loihiensis reveals amino acid fermentation as a source of carbon and
RT   energy.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:18036-18041(2004).
CC   -!- FUNCTION: Multidrug efflux pump. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC       2.A.66.1) family. {ECO:0000305}.
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DR   EMBL; AE017340; AAV82674.1; -; Genomic_DNA.
DR   RefSeq; WP_011235074.1; NC_006512.1.
DR   AlphaFoldDB; Q5QWR6; -.
DR   SMR; Q5QWR6; -.
DR   STRING; 283942.IL1842; -.
DR   DNASU; 3171968; -.
DR   EnsemblBacteria; AAV82674; AAV82674; IL1842.
DR   KEGG; ilo:IL1842; -.
DR   eggNOG; COG0534; Bacteria.
DR   HOGENOM; CLU_012893_6_0_6; -.
DR   OMA; EFWILLK; -.
DR   OrthoDB; 1415498at2; -.
DR   Proteomes; UP000001171; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR002528; MATE_fam.
DR   Pfam; PF01554; MatE; 2.
DR   PIRSF; PIRSF006603; DinF; 1.
DR   TIGRFAMs; TIGR00797; matE; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell inner membrane; Cell membrane; Ion transport; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..462
FT                   /note="Probable multidrug resistance protein NorM"
FT                   /id="PRO_0000164220"
FT   TRANSMEM        56..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        90..112
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        127..149
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        161..183
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        193..215
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        243..265
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        285..307
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        319..341
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        356..378
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        391..410
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        420..442
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   462 AA;  50283 MW;  4E3D386B7C62449E CRC64;
     MNWWTNNKGE FNKLAKLTGP ILVAQLTQML MSVVDTVMAG RKGALDLAAV SVGGSIFVPA
     TLLVFGLALA LAPIISHLDG SNSHRRIANI LQQGLYACAI VGVITLIGMS SAPWLLDIME
     VEDDFRAITL DYLFYISWGI PGFVIYAVLR NFCEGLSNTM PSLIIGFIGL LINIPANYIF
     VYGKFGMPEL GGAGCGLATA IVLWGMALSM VVYTFTAKRY KRLRLLRRWY RPNWDDVTYV
     IRIGFPISMS LFFEVSLFAA VALLIAPLGP TVVSAHQIAL NISSLVYMVP LSISMAVTLR
     VGFALGAGNP KNAMLSFKLA MLFGGVFAGV NGLIMYLGGG WLASLYTPDK DIINLAATLM
     GLAAIFTVSD TFQAISIGTL RGYKDTKYPM ILAFISYWPF GLTVGYILGL TDWVVPAMGA
     AGFWIGFISG LSVAAVLLSL RLRRVSRRYE RKHFREQLNS AA