NORM_LISMF
ID NORM_LISMF Reviewed; 456 AA.
AC Q71YH0;
DT 29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 95.
DE RecName: Full=Probable multidrug resistance protein NorM;
DE AltName: Full=Multidrug-efflux transporter;
GN Name=norM; OrderedLocusNames=LMOf2365_1874;
OS Listeria monocytogenes serotype 4b (strain F2365).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Listeriaceae; Listeria.
OX NCBI_TaxID=265669;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F2365;
RX PubMed=15115801; DOI=10.1093/nar/gkh562;
RA Nelson K.E., Fouts D.E., Mongodin E.F., Ravel J., DeBoy R.T., Kolonay J.F.,
RA Rasko D.A., Angiuoli S.V., Gill S.R., Paulsen I.T., Peterson J.D.,
RA White O., Nelson W.C., Nierman W.C., Beanan M.J., Brinkac L.M.,
RA Daugherty S.C., Dodson R.J., Durkin A.S., Madupu R., Haft D.H.,
RA Selengut J., Van Aken S.E., Khouri H.M., Fedorova N., Forberger H.A.,
RA Tran B., Kathariou S., Wonderling L.D., Uhlich G.A., Bayles D.O.,
RA Luchansky J.B., Fraser C.M.;
RT "Whole genome comparisons of serotype 4b and 1/2a strains of the food-borne
RT pathogen Listeria monocytogenes reveal new insights into the core genome
RT components of this species.";
RL Nucleic Acids Res. 32:2386-2395(2004).
CC -!- FUNCTION: Multidrug efflux pump. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC 2.A.66.1) family. {ECO:0000305}.
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DR EMBL; AE017262; AAT04644.1; -; Genomic_DNA.
DR RefSeq; WP_009929777.1; NC_002973.6.
DR AlphaFoldDB; Q71YH0; -.
DR SMR; Q71YH0; -.
DR KEGG; lmf:LMOf2365_1874; -.
DR HOGENOM; CLU_012893_6_0_9; -.
DR OMA; TGNQKVG; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; ISS:JCVI.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR GO; GO:0009410; P:response to xenobiotic stimulus; ISS:JCVI.
DR GO; GO:0006855; P:xenobiotic transmembrane transport; ISS:JCVI.
DR InterPro; IPR002528; MATE_fam.
DR Pfam; PF01554; MatE; 2.
DR PIRSF; PIRSF006603; DinF; 1.
DR TIGRFAMs; TIGR00797; matE; 1.
PE 3: Inferred from homology;
KW Antiport; Cell membrane; Ion transport; Membrane; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..456
FT /note="Probable multidrug resistance protein NorM"
FT /id="PRO_0000164222"
FT TRANSMEM 13..34
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 54..76
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 95..117
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 132..154
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 161..183
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 193..215
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..266
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 286..308
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 321..343
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 358..380
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 387..409
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 414..436
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 456 AA; 49589 MW; E01BBD211B544844 CRC64;
MQQTVTYGAK WKQFLTIFTP IVITQLTLFS MTFFDTTMSG NYSNQALAGV AIGSSFWAPV
NAAFSGLLMA ITPIIAQLIG AKKEKQVKNT VHNGLYIALF LAFILILINF LVVPTILTHM
PVTAEVAGIA RHFLNGICIG IPAFFISAIL RSFIDSLGLT RVTMLITLCT VPFNIFLNYC
FIFGNFGFPE MGGAGSGYAT GITYWLVVLV SVILIQTQTR LRKFGIFKGL TALRFSKIKE
IIGIGVPNGL TILFETSIFS AVTILMGAFG TETIAAHQSA NSVCTLLYAF PLSVASTLTI
LGGYETGAKR LKDAKQYRHI GMAAAIFIGC VNGAILFFFR DIIAGFYTND PALSNLIMHF
LVYAILFQFA DAVLSPVLGA LRGYKDVTVT SIVAFISYWL IGLPVGYGLS FTNLGPFGYW
IGLSTGLFVA AFILSIRVRK TEQKLSFNTK DAEISS