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NORM_LISMF
ID   NORM_LISMF              Reviewed;         456 AA.
AC   Q71YH0;
DT   29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Probable multidrug resistance protein NorM;
DE   AltName: Full=Multidrug-efflux transporter;
GN   Name=norM; OrderedLocusNames=LMOf2365_1874;
OS   Listeria monocytogenes serotype 4b (strain F2365).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Listeriaceae; Listeria.
OX   NCBI_TaxID=265669;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=F2365;
RX   PubMed=15115801; DOI=10.1093/nar/gkh562;
RA   Nelson K.E., Fouts D.E., Mongodin E.F., Ravel J., DeBoy R.T., Kolonay J.F.,
RA   Rasko D.A., Angiuoli S.V., Gill S.R., Paulsen I.T., Peterson J.D.,
RA   White O., Nelson W.C., Nierman W.C., Beanan M.J., Brinkac L.M.,
RA   Daugherty S.C., Dodson R.J., Durkin A.S., Madupu R., Haft D.H.,
RA   Selengut J., Van Aken S.E., Khouri H.M., Fedorova N., Forberger H.A.,
RA   Tran B., Kathariou S., Wonderling L.D., Uhlich G.A., Bayles D.O.,
RA   Luchansky J.B., Fraser C.M.;
RT   "Whole genome comparisons of serotype 4b and 1/2a strains of the food-borne
RT   pathogen Listeria monocytogenes reveal new insights into the core genome
RT   components of this species.";
RL   Nucleic Acids Res. 32:2386-2395(2004).
CC   -!- FUNCTION: Multidrug efflux pump. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC       2.A.66.1) family. {ECO:0000305}.
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DR   EMBL; AE017262; AAT04644.1; -; Genomic_DNA.
DR   RefSeq; WP_009929777.1; NC_002973.6.
DR   AlphaFoldDB; Q71YH0; -.
DR   SMR; Q71YH0; -.
DR   KEGG; lmf:LMOf2365_1874; -.
DR   HOGENOM; CLU_012893_6_0_9; -.
DR   OMA; TGNQKVG; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; ISS:JCVI.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0009410; P:response to xenobiotic stimulus; ISS:JCVI.
DR   GO; GO:0006855; P:xenobiotic transmembrane transport; ISS:JCVI.
DR   InterPro; IPR002528; MATE_fam.
DR   Pfam; PF01554; MatE; 2.
DR   PIRSF; PIRSF006603; DinF; 1.
DR   TIGRFAMs; TIGR00797; matE; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell membrane; Ion transport; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..456
FT                   /note="Probable multidrug resistance protein NorM"
FT                   /id="PRO_0000164222"
FT   TRANSMEM        13..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        54..76
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        95..117
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        132..154
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        161..183
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        193..215
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        244..266
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        286..308
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        321..343
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        358..380
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        387..409
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        414..436
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   456 AA;  49589 MW;  E01BBD211B544844 CRC64;
     MQQTVTYGAK WKQFLTIFTP IVITQLTLFS MTFFDTTMSG NYSNQALAGV AIGSSFWAPV
     NAAFSGLLMA ITPIIAQLIG AKKEKQVKNT VHNGLYIALF LAFILILINF LVVPTILTHM
     PVTAEVAGIA RHFLNGICIG IPAFFISAIL RSFIDSLGLT RVTMLITLCT VPFNIFLNYC
     FIFGNFGFPE MGGAGSGYAT GITYWLVVLV SVILIQTQTR LRKFGIFKGL TALRFSKIKE
     IIGIGVPNGL TILFETSIFS AVTILMGAFG TETIAAHQSA NSVCTLLYAF PLSVASTLTI
     LGGYETGAKR LKDAKQYRHI GMAAAIFIGC VNGAILFFFR DIIAGFYTND PALSNLIMHF
     LVYAILFQFA DAVLSPVLGA LRGYKDVTVT SIVAFISYWL IGLPVGYGLS FTNLGPFGYW
     IGLSTGLFVA AFILSIRVRK TEQKLSFNTK DAEISS
 
 
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