ID   NORM_LISMO              Reviewed;         456 AA.
AC   Q8Y654;
DT   31-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Probable multidrug resistance protein NorM;
DE   AltName: Full=Multidrug-efflux transporter;
GN   Name=norM; OrderedLocusNames=lmo1846;
OS   Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Listeriaceae; Listeria.
OX   NCBI_TaxID=169963;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-679 / EGD-e;
RX   PubMed=11679669; DOI=10.1126/science.1063447;
RA   Glaser P., Frangeul L., Buchrieser C., Rusniok C., Amend A., Baquero F.,
RA   Berche P., Bloecker H., Brandt P., Chakraborty T., Charbit A.,
RA   Chetouani F., Couve E., de Daruvar A., Dehoux P., Domann E.,
RA   Dominguez-Bernal G., Duchaud E., Durant L., Dussurget O., Entian K.-D.,
RA   Fsihi H., Garcia-del Portillo F., Garrido P., Gautier L., Goebel W.,
RA   Gomez-Lopez N., Hain T., Hauf J., Jackson D., Jones L.-M., Kaerst U.,
RA   Kreft J., Kuhn M., Kunst F., Kurapkat G., Madueno E., Maitournam A.,
RA   Mata Vicente J., Ng E., Nedjari H., Nordsiek G., Novella S., de Pablos B.,
RA   Perez-Diaz J.-C., Purcell R., Remmel B., Rose M., Schlueter T., Simoes N.,
RA   Tierrez A., Vazquez-Boland J.-A., Voss H., Wehland J., Cossart P.;
RT   "Comparative genomics of Listeria species.";
RL   Science 294:849-852(2001).
CC   -!- FUNCTION: Multidrug efflux pump. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC       2.A.66.1) family. {ECO:0000305}.
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DR   EMBL; AL591981; CAC99924.1; -; Genomic_DNA.
DR   PIR; AF1305; AF1305.
DR   RefSeq; NP_465371.1; NC_003210.1.
DR   RefSeq; WP_003724070.1; NZ_CP023861.1.
DR   AlphaFoldDB; Q8Y654; -.
DR   SMR; Q8Y654; -.
DR   STRING; 169963.lmo1846; -.
DR   PaxDb; Q8Y654; -.
DR   EnsemblBacteria; CAC99924; CAC99924; CAC99924.
DR   GeneID; 985857; -.
DR   KEGG; lmo:lmo1846; -.
DR   PATRIC; fig|169963.11.peg.1891; -.
DR   eggNOG; COG0534; Bacteria.
DR   HOGENOM; CLU_012893_6_0_9; -.
DR   OMA; TGNQKVG; -.
DR   PhylomeDB; Q8Y654; -.
DR   BioCyc; LMON169963:LMO1846-MON; -.
DR   Proteomes; UP000000817; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR002528; MATE_fam.
DR   Pfam; PF01554; MatE; 2.
DR   PIRSF; PIRSF006603; DinF; 1.
DR   TIGRFAMs; TIGR00797; matE; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell membrane; Ion transport; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..456
FT                   /note="Probable multidrug resistance protein NorM"
FT                   /id="PRO_0000164223"
FT   TRANSMEM        13..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        54..76
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        95..117
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        132..154
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        161..183
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        193..215
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        244..266
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        286..308
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        321..343
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        358..380
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        387..409
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        414..436
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   456 AA;  49656 MW;  A4232F1FAD8BE746 CRC64;
     MQQTVTYGAK WKQFLTIFTP IVITQLTLFS MTFFDTTMSG NYSNQALAGV AIGSSFWAPV
     NAAFSGLLMA ITPIIAQLIG AKKEKQVKNT VHNGLYIALF LAFILILINF LVVPMILTHM
     PVTAEVADIA RHFLNGICIG IPAFFISAIL RSFIDSLGLT RVTMLITLCT VPFNIFLNYC
     FIFGNFGFPE MGGAGSGYAT GITYWLVVLV SVILIQTQTR LRKFGVFKGL TALRFSKIKE
     IIGIGVPNGL TILFETSIFS AVTILMGAFG TETIAAHQSA NSVCTLLYAF PLSVASTLTI
     LGGYETGAKR LKDAKQYRHI GMAAAILIGC VNGAILFFFR DIIAGFYTND PALSNLIMHF
     LVYAILFQFA DAVLSPVLGA LRGYKDVTVT SIVAFISYWL IGLPVGYGLS FTNLGPFGYW
     IGLSTGLFVA AFILSIRVRK TEQKLSFNTK DAEISN