ID   NORM_MANSM              Reviewed;         465 AA.
AC   Q65SY9;
DT   29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Probable multidrug resistance protein NorM;
DE   AltName: Full=Multidrug-efflux transporter;
GN   Name=norM; OrderedLocusNames=MS1314;
OS   Mannheimia succiniciproducens (strain MBEL55E).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Basfia.
OX   NCBI_TaxID=221988;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MBEL55E;
RX   PubMed=15378067; DOI=10.1038/nbt1010;
RA   Hong S.H., Kim J.S., Lee S.Y., In Y.H., Choi S.S., Rih J.-K., Kim C.H.,
RA   Jeong H., Hur C.G., Kim J.J.;
RT   "The genome sequence of the capnophilic rumen bacterium Mannheimia
RT   succiniciproducens.";
RL   Nat. Biotechnol. 22:1275-1281(2004).
CC   -!- FUNCTION: Multidrug efflux pump. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC       2.A.66.1) family. {ECO:0000305}.
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DR   EMBL; AE016827; AAU37921.1; -; Genomic_DNA.
DR   RefSeq; WP_011200488.1; NC_006300.1.
DR   AlphaFoldDB; Q65SY9; -.
DR   SMR; Q65SY9; -.
DR   STRING; 221988.MS1314; -.
DR   EnsemblBacteria; AAU37921; AAU37921; MS1314.
DR   KEGG; msu:MS1314; -.
DR   eggNOG; COG0534; Bacteria.
DR   HOGENOM; CLU_012893_6_0_6; -.
DR   OMA; TGNQKVG; -.
DR   OrthoDB; 1415498at2; -.
DR   Proteomes; UP000000607; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR002528; MATE_fam.
DR   Pfam; PF01554; MatE; 2.
DR   PIRSF; PIRSF006603; DinF; 1.
DR   TIGRFAMs; TIGR00797; matE; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell inner membrane; Cell membrane; Ion transport; Membrane;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..465
FT                   /note="Probable multidrug resistance protein NorM"
FT                   /id="PRO_0000164224"
FT   TRANSMEM        50..72
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        92..114
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        127..149
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        164..186
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        193..215
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        248..270
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        283..305
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        320..342
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        393..412
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        422..444
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   465 AA;  50981 MW;  C476417C0E3AFB82 CRC64;
     MQKITHWQEY KIEAKSLILL SLPILLAQIA QNSMGLVDTI MAGRVSAADM AAISVGASIW
     MPLVLFGQGL LLALPPTISY LNGSAQRHRI AHQVRQGIWI ILFSIVPLAL LIYHSDTVIN
     RMGMEEHLAQ ITIKYLHAML FGLPAYLLLV NFRCLNDGLA KTKPAMIITL IGLLLNIPLN
     YIFIYGKLGV PAFGAVGCGI ATTIVNWIMC ILMISYTKSA RNQRDLKVFE NIIELPNPAT
     LKKLFKLGLP IAIAICSEVA LFALTSLLLS PLGTNAVASH QIALNTSSFI FMLPMSLGMA
     TTILVGQSLG ERSPLKAKDI SYVALFIGLA TATLTAFLTV VLRYQIAGIF VKDTEVISLA
     ASLLLLNALY QFSDAVQVVV GGALRGYKDT KAILYITLFC YWVLGMPIGY ILSRTDLITA
     HMGPTGFWIA FVVSLTVAAV LLFYRMYKIQ KQSDEQLLTK LEKLK