ID   NORM_OCEIH              Reviewed;         447 AA.
AC   Q8CUL5;
DT   29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   29-MAR-2005, sequence version 2.
DT   25-MAY-2022, entry version 101.
DE   RecName: Full=Probable multidrug resistance protein NorM;
DE   AltName: Full=Multidrug-efflux transporter;
GN   Name=norM; OrderedLocusNames=OB1092;
OS   Oceanobacillus iheyensis (strain DSM 14371 / CIP 107618 / JCM 11309 / KCTC
OS   3954 / HTE831).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Oceanobacillus.
OX   NCBI_TaxID=221109;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 14371 / CIP 107618 / JCM 11309 / KCTC 3954 / HTE831;
RX   PubMed=12235376; DOI=10.1093/nar/gkf526;
RA   Takami H., Takaki Y., Uchiyama I.;
RT   "Genome sequence of Oceanobacillus iheyensis isolated from the Iheya Ridge
RT   and its unexpected adaptive capabilities to extreme environments.";
RL   Nucleic Acids Res. 30:3927-3935(2002).
CC   -!- FUNCTION: Multidrug efflux pump. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC       2.A.66.1) family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC13048.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BA000028; BAC13048.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_011065493.1; NC_004193.1.
DR   AlphaFoldDB; Q8CUL5; -.
DR   SMR; Q8CUL5; -.
DR   STRING; 221109.22776773; -.
DR   EnsemblBacteria; BAC13048; BAC13048; BAC13048.
DR   KEGG; oih:OB1092; -.
DR   eggNOG; COG0534; Bacteria.
DR   HOGENOM; CLU_012893_6_0_9; -.
DR   OrthoDB; 1415498at2; -.
DR   PhylomeDB; Q8CUL5; -.
DR   Proteomes; UP000000822; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR002528; MATE_fam.
DR   Pfam; PF01554; MatE; 2.
DR   PIRSF; PIRSF006603; DinF; 1.
DR   TIGRFAMs; TIGR00797; matE; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell membrane; Ion transport; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..447
FT                   /note="Probable multidrug resistance protein NorM"
FT                   /id="PRO_0000164227"
FT   TRANSMEM        11..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        53..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        95..117
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        132..154
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        161..183
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        193..215
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        244..266
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        286..308
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        317..339
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        359..381
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        388..410
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        420..442
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   447 AA;  49049 MW;  2434756DC742EDC4 CRC64;
     MYQTTTLKDK IKLFIIILLP ILITQVSINL MSFFDTMMSG QFSARDLAGV AIGSSLWVPI
     LTGINGIVLS ITPIIAHLIG AKNKKDIPQV IQQGIYLSFV LSIIIIVIGG IALDPILQAM
     SLEKEVQRIA KYYLITLGTG IVPLFLFHTI RSFMDGLGQT RSSMIIILIS LPINAVLNYI
     LIFGKFGIPA FGGIGAGIAT SLTYWIISGI SIFMIHRVYP FHSYKVFQKI LPPTLSYWAD
     QLKIGLPIGL AIFFETSIFS AVTLLMSEYN TNTIAAHQAA MNFASLLYML PLSVGMALTI
     AVGFEVGAKR LHDAKRYTYL GIMGGLFIAI FAGIILYTFD DVVARLYNSN PEVIELTKQF
     IIFAIFYQLA DAIGAPIQGA LRGYKDVNMT LVIALISYWI IGLPTGYLLA NYTALEPFGY
     WVGIIVGLST GAIALLARLL FIQKKSV