ID   NORM_PASMU              Reviewed;         464 AA.
AC   Q9CMZ9;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   25-MAY-2022, entry version 112.
DE   RecName: Full=Probable multidrug resistance protein NorM;
DE   AltName: Full=Multidrug-efflux transporter;
GN   Name=norM; OrderedLocusNames=PM0651;
OS   Pasteurella multocida (strain Pm70).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Pasteurella.
OX   NCBI_TaxID=272843;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Pm70;
RX   PubMed=11248100; DOI=10.1073/pnas.051634598;
RA   May B.J., Zhang Q., Li L.L., Paustian M.L., Whittam T.S., Kapur V.;
RT   "Complete genomic sequence of Pasteurella multocida Pm70.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:3460-3465(2001).
CC   -!- FUNCTION: Multidrug efflux pump. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC       2.A.66.1) family. {ECO:0000305}.
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DR   EMBL; AE004439; AAK02735.1; -; Genomic_DNA.
DR   RefSeq; WP_005726519.1; NC_002663.1.
DR   AlphaFoldDB; Q9CMZ9; -.
DR   SMR; Q9CMZ9; -.
DR   STRING; 747.DR93_1481; -.
DR   EnsemblBacteria; AAK02735; AAK02735; PM0651.
DR   KEGG; pmu:PM0651; -.
DR   HOGENOM; CLU_012893_6_0_6; -.
DR   OMA; TGNQKVG; -.
DR   Proteomes; UP000000809; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR002528; MATE_fam.
DR   Pfam; PF01554; MatE; 2.
DR   PIRSF; PIRSF006603; DinF; 1.
DR   TIGRFAMs; TIGR00797; matE; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell inner membrane; Cell membrane; Ion transport; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..464
FT                   /note="Probable multidrug resistance protein NorM"
FT                   /id="PRO_0000164228"
FT   TRANSMEM        16..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        51..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        97..117
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        129..149
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        164..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        194..214
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        248..268
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        285..305
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        321..341
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        355..375
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        391..411
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        423..443
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   464 AA;  50667 MW;  A9945110F05AE1C6 CRC64;
     MKFIDFSAYK VEAKKLLLIA LPILLAQIAQ NSMGLVDTIM SGRVSSADMA AISVGASIWF
     PLVLFGHGLL LALPPTISYL NGSGKRDQIA HQVRQGIWII LFSCLPLGIL IYYSNLVFDY
     MQVEDHLKEI TIGYLHAMIW GLPAYLLMIN FRCLNDGIAK TKPAMVITFL GLGLNIPLNY
     IFIYGKLGIP AFGAVGCGIA TAIVNWFMCI LMIAYCKNAR NQRDLKVFAK ILEKPNFTTL
     KKLLNLGFPI AVALFCEVAL FALTALLLSP LGTDIVASHQ IALNTSSFLF MLPMSLGMAA
     TILVGQRLGE GAADKAKQVS YSALIVGLLI AVITATLTVI FRVEIAEIFV KDRDVIAMAG
     TLLLIAALYQ FSDTVQVVAG GALRGYKDTK AILYITLFCY WVVGMPMGYT LARTDLLMPA
     LGAEGFWIGF VVSLTIAATL LMIRMRKIQA QPDAILFAKL EKLK