ID   NORM_PHOLL              Reviewed;         453 AA.
AC   Q7N1G0;
DT   29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Probable multidrug resistance protein NorM;
DE   AltName: Full=Multidrug-efflux transporter;
GN   Name=norM; OrderedLocusNames=plu3516;
OS   Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 /
OS   TT01).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Photorhabdus.
OX   NCBI_TaxID=243265;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 15139 / CIP 105565 / TT01;
RX   PubMed=14528314; DOI=10.1038/nbt886;
RA   Duchaud E., Rusniok C., Frangeul L., Buchrieser C., Givaudan A.,
RA   Taourit S., Bocs S., Boursaux-Eude C., Chandler M., Charles J.-F.,
RA   Dassa E., Derose R., Derzelle S., Freyssinet G., Gaudriault S., Medigue C.,
RA   Lanois A., Powell K., Siguier P., Vincent R., Wingate V., Zouine M.,
RA   Glaser P., Boemare N., Danchin A., Kunst F.;
RT   "The genome sequence of the entomopathogenic bacterium Photorhabdus
RT   luminescens.";
RL   Nat. Biotechnol. 21:1307-1313(2003).
CC   -!- FUNCTION: Multidrug efflux pump. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC       2.A.66.1) family. {ECO:0000305}.
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DR   EMBL; BX571870; CAE15889.1; -; Genomic_DNA.
DR   RefSeq; WP_011147696.1; NC_005126.1.
DR   AlphaFoldDB; Q7N1G0; -.
DR   SMR; Q7N1G0; -.
DR   EnsemblBacteria; CAE15889; CAE15889; plu3516.
DR   GeneID; 24169680; -.
DR   KEGG; plu:plu3516; -.
DR   eggNOG; COG0534; Bacteria.
DR   HOGENOM; CLU_012893_6_0_6; -.
DR   OMA; LMPAWGY; -.
DR   OrthoDB; 1415498at2; -.
DR   BioCyc; PLUM243265:PLU_RS17440-MON; -.
DR   Proteomes; UP000002514; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR002528; MATE_fam.
DR   Pfam; PF01554; MatE; 2.
DR   PIRSF; PIRSF006603; DinF; 1.
DR   TIGRFAMs; TIGR00797; matE; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell inner membrane; Cell membrane; Ion transport; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..453
FT                   /note="Probable multidrug resistance protein NorM"
FT                   /id="PRO_0000164229"
FT   TRANSMEM        13..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        50..72
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        93..115
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        125..147
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        160..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        192..214
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        238..260
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        275..297
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        318..340
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        350..372
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        385..407
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        417..439
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   453 AA;  49969 MW;  849C762F3D264EC6 CRC64;
     MAKFSNWREL KQLLFFSFPI IVSQIARTAM SFVDIVMSGH YATADLAAVT LGSSIWFPIF
     VLGYGTIIML AADVAKQKAQ HDDEGIKDSL KNYLFLAVIL SIPIIILLML VSWLLSFIGI
     DEHILEITQG YVIALACGVP SVMIFNVFRS FLQGLEDTKI AMYLSAGALL LNIPLNYILI
     YGKLGLPEMG GIGAGITTAI INNLIAVCLI IYFLLKKEYR RYRPDFSLPK YNSLIRTFYI
     GMPSGLALFV EMVFLDVIAI TAAPLGAQVI AAHNIMLNIT SIIYTITGGI AAAVTVRVGS
     YIGKRDKISL TGTIKISIAL ILSISAVIGV LIYYFAGSFI SLYTNDNGVI IIALNIIFLL
     CLFQFFDSCQ AALSGILRGF HDTRSVFYAP LFGYWLVGLP LGFILALTDW VTERMGIIGF
     WYGLVLGLFV NAILLFIILK VRQRGMISRL ISY