NORM_PHOPR
ID NORM_PHOPR Reviewed; 456 AA.
AC Q6LQ49;
DT 29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 93.
DE RecName: Full=Multidrug resistance protein NorM;
DE AltName: Full=Multidrug-efflux transporter;
DE AltName: Full=Na(+)/drug antiporter;
GN Name=norM; OrderedLocusNames=PBPRA2180;
OS Photobacterium profundum (strain SS9).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Photobacterium.
OX NCBI_TaxID=298386;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-1253 / SS9;
RX PubMed=15746425; DOI=10.1126/science.1103341;
RA Vezzi A., Campanaro S., D'Angelo M., Simonato F., Vitulo N., Lauro F.M.,
RA Cestaro A., Malacrida G., Simionati B., Cannata N., Romualdi C.,
RA Bartlett D.H., Valle G.;
RT "Life at depth: Photobacterium profundum genome sequence and expression
RT analysis.";
RL Science 307:1459-1461(2005).
CC -!- FUNCTION: Multidrug efflux pump that functions as a Na(+)/drug
CC antiporter. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC 2.A.66.1) family. {ECO:0000305}.
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DR EMBL; CR378670; CAG20577.1; -; Genomic_DNA.
DR RefSeq; WP_011218868.1; NC_006370.1.
DR AlphaFoldDB; Q6LQ49; -.
DR SMR; Q6LQ49; -.
DR STRING; 298386.PBPRA2180; -.
DR EnsemblBacteria; CAG20577; CAG20577; PBPRA2180.
DR KEGG; ppr:PBPRA2180; -.
DR eggNOG; COG0534; Bacteria.
DR HOGENOM; CLU_012893_6_0_6; -.
DR OMA; TGNQKVG; -.
DR OrthoDB; 1415498at2; -.
DR Proteomes; UP000000593; Chromosome 1.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR002528; MATE_fam.
DR Pfam; PF01554; MatE; 2.
DR PIRSF; PIRSF006603; DinF; 1.
DR TIGRFAMs; TIGR00797; matE; 1.
PE 3: Inferred from homology;
KW Antiport; Cell inner membrane; Cell membrane; Ion transport; Membrane;
KW Reference proteome; Sodium; Sodium transport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..456
FT /note="Multidrug resistance protein NorM"
FT /id="PRO_0000164230"
FT TRANSMEM 11..31
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 93..113
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 126..146
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 159..179
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 193..213
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 242..262
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 276..296
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 315..335
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 349..369
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 391..411
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 417..437
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 456 AA; 49622 MW; 8C268177E7B163A0 CRC64;
MHNYRRETRQ LLTLAIPVLI ASVAQTSMGF VDTVMAGGVS ATDMAAVSVA SSIWLPAILF
GVGLLIALVP IVAQLNGSGK KDKIPFEVQH GFLLALIISV PIMAILYNAG MLIDYMDVEP
ILAEKTIGYL HAVVYAVPAF LLFQTLRSFA EGLSLTVPGM VIGFIGLMAN IPLNWIFVYG
KFGFPEMGGV GCGVATAIVY WLMFFSMLVY VLVNKRLKRA GLFDVWYKPQ PKAVLRLFKL
GFPVAASMFF EVSLFAVIAL MISPLGSIIV ASHQVAINFS SLVFMLPMSL GIALSIRVGH
MLGEQDLVGA KIASHCGLIV GLIMSLMTAI LTIIYREEIA LLYTDNADVI VLAGQLLFLA
AVYQCSDAIQ VVAAGALRGY KDMRAIFIRT FIAYWMLGLP VGYILGMTDW IVEPMGPHGF
WIGNIVGLSA AAIMLAMRLR WIQCQSDEFQ IAMSLK
