ID   NORM_PSEAE              Reviewed;         488 AA.
AC   Q9HTR0;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=Probable multidrug resistance protein NorM;
DE   AltName: Full=Multidrug-efflux transporter;
GN   Name=norM; OrderedLocusNames=PA5294;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
CC   -!- FUNCTION: Multidrug efflux pump. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC       2.A.66.1) family. {ECO:0000305}.
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DR   EMBL; AE004091; AAG08679.1; -; Genomic_DNA.
DR   PIR; A82984; A82984.
DR   RefSeq; NP_253981.1; NC_002516.2.
DR   RefSeq; WP_003114349.1; NZ_QZGE01000020.1.
DR   AlphaFoldDB; Q9HTR0; -.
DR   SMR; Q9HTR0; -.
DR   STRING; 287.DR97_2666; -.
DR   PaxDb; Q9HTR0; -.
DR   EnsemblBacteria; AAG08679; AAG08679; PA5294.
DR   GeneID; 880556; -.
DR   KEGG; pae:PA5294; -.
DR   PATRIC; fig|208964.12.peg.5548; -.
DR   PseudoCAP; PA5294; -.
DR   HOGENOM; CLU_012893_6_3_6; -.
DR   InParanoid; Q9HTR0; -.
DR   OMA; AAWFELF; -.
DR   PhylomeDB; Q9HTR0; -.
DR   BioCyc; PAER208964:G1FZ6-5415-MON; -.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0098567; C:periplasmic side of plasma membrane; ISS:PseudoCAP.
DR   GO; GO:0005886; C:plasma membrane; ISS:PseudoCAP.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0046677; P:response to antibiotic; IBA:GO_Central.
DR   InterPro; IPR002528; MATE_fam.
DR   Pfam; PF01554; MatE; 2.
DR   PIRSF; PIRSF006603; DinF; 1.
DR   TIGRFAMs; TIGR00797; matE; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell inner membrane; Cell membrane; Ion transport; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..488
FT                   /note="Probable multidrug resistance protein NorM"
FT                   /id="PRO_0000164232"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        97..117
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        127..147
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        159..179
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        190..210
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        247..267
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        271..291
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        317..337
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        355..375
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        393..413
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        421..441
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   488 AA;  50559 MW;  8202CBB392C0F9FD CRC64;
     MSSPSLVELK AILRLAGPLI AAQLAYVAMV FTDTVMMGKL GPDALAAGGL GAVSYAFVST
     FCVGVVAAVG NLVAIRHGCD DAAGAAAAAR SGLWVGAALA LAAGLLLWNL RPLLLVFGQA
     PQTVDGAMQF LHSLTFALPG YMAFMVLRGF TSAIDRAGPV MAISVLGALA NLALNYSFIE
     GLFGLPRLGL AGIGLVTALV MNCMPLLLAL YIRLQPAYAE YSLLRGLGRP QRAMVEEILR
     LGLPIGGTYA VESGMFTVAT LCMGIIGDHA LAAHQIAIQA VYVAFMVPVG LSYATTYRIG
     QHFGAGRLLE ARRAGRVGIG FGALCMLLFA GLFWWMPEAI IGLFLDRDAP ANREVAAMAV
     SLLAIAAWFE LFDGTQNVAM GAIRGLKDAR TTFLVGLACY WLVGVPLACL LAFAAGWGAA
     GVWWGLAGGL ACAAIGLTLA FEWKTARLLP KATASEASAL NCRAAGRGAP SARLCPGNAP
     VPPTAAAD