ID   NORM_PSEPK              Reviewed;         462 AA.
AC   Q88CB9;
DT   29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Probable multidrug resistance protein NorM;
DE   AltName: Full=Multidrug-efflux transporter;
GN   Name=norM; OrderedLocusNames=PP_5262;
OS   Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950
OS   / KT2440).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=160488;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440;
RX   PubMed=12534463; DOI=10.1046/j.1462-2920.2002.00366.x;
RA   Nelson K.E., Weinel C., Paulsen I.T., Dodson R.J., Hilbert H.,
RA   Martins dos Santos V.A.P., Fouts D.E., Gill S.R., Pop M., Holmes M.,
RA   Brinkac L.M., Beanan M.J., DeBoy R.T., Daugherty S.C., Kolonay J.F.,
RA   Madupu R., Nelson W.C., White O., Peterson J.D., Khouri H.M., Hance I.,
RA   Chris Lee P., Holtzapple E.K., Scanlan D., Tran K., Moazzez A.,
RA   Utterback T.R., Rizzo M., Lee K., Kosack D., Moestl D., Wedler H.,
RA   Lauber J., Stjepandic D., Hoheisel J., Straetz M., Heim S., Kiewitz C.,
RA   Eisen J.A., Timmis K.N., Duesterhoeft A., Tuemmler B., Fraser C.M.;
RT   "Complete genome sequence and comparative analysis of the metabolically
RT   versatile Pseudomonas putida KT2440.";
RL   Environ. Microbiol. 4:799-808(2002).
CC   -!- FUNCTION: Multidrug efflux pump. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC       2.A.66.1) family. {ECO:0000305}.
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DR   EMBL; AE015451; AAN70827.1; -; Genomic_DNA.
DR   RefSeq; NP_747363.1; NC_002947.4.
DR   RefSeq; WP_010955775.1; NC_002947.4.
DR   AlphaFoldDB; Q88CB9; -.
DR   SMR; Q88CB9; -.
DR   STRING; 160488.PP_5262; -.
DR   EnsemblBacteria; AAN70827; AAN70827; PP_5262.
DR   KEGG; ppu:PP_5262; -.
DR   PATRIC; fig|160488.4.peg.5614; -.
DR   eggNOG; COG0534; Bacteria.
DR   HOGENOM; CLU_012893_6_3_6; -.
DR   OMA; AAWFELF; -.
DR   PhylomeDB; Q88CB9; -.
DR   BioCyc; PPUT160488:G1G01-5619-MON; -.
DR   Proteomes; UP000000556; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR002528; MATE_fam.
DR   Pfam; PF01554; MatE; 2.
DR   PIRSF; PIRSF006603; DinF; 1.
DR   TIGRFAMs; TIGR00797; matE; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell inner membrane; Cell membrane; Ion transport; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..462
FT                   /note="Probable multidrug resistance protein NorM"
FT                   /id="PRO_0000164233"
FT   TRANSMEM        12..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        51..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        93..115
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        125..147
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        160..179
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        189..211
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        238..260
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        275..297
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        318..340
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        350..372
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        393..415
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        419..441
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   462 AA;  48856 MW;  CBDDDA75330F1BA8 CRC64;
     MHVAPTTELK ALLRLAGPLI ASQLAHMLMV LTDTLMMARI SPQALAGGGL GAASYSFVSI
     FCLGVIAAVG TLVAIRKGAN DIEGATRLAQ NGLWLAWALA LFAALVLWNL EPVLLLFGQK
     PENVASAAEF LTLLPLALPG YLTFMALRGF TSALGRSTPV MVISLFGTVL NYLFNVALIE
     GMFGLPKLGL MGIGLVTAVV SMGMATALAL YIRWHPAYTA YPLRKGLSRP SLAALRELWR
     LGLPIGGTYM VEVGLFAFAA LCMGVLGSTE LAAHQIALQI VSTAFMVPTG LSYAVTMRVG
     LYYGAGNLLA ARSAGRVGIG FGAMIMFAFA TLFLLLPEAL VGLFIDRNDP AFAAIFQVAV
     QLLMVAAWFE LFDGMQTIAM GSIRGLKDAK TTFLIGLVCY WLVGAPSAWL FTFTLGGGAV
     GIWWGLALGL ACAAVALTFG FEWRMKRLLG KAGVRTEAAV SA