ID   NORM_PSESM              Reviewed;         460 AA.
AC   Q88BA2;
DT   29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Probable multidrug resistance protein NorM;
DE   AltName: Full=Multidrug-efflux transporter;
GN   Name=norM; OrderedLocusNames=PSPTO_0115;
OS   Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=223283;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-871 / DC3000;
RX   PubMed=12928499; DOI=10.1073/pnas.1731982100;
RA   Buell C.R., Joardar V., Lindeberg M., Selengut J., Paulsen I.T.,
RA   Gwinn M.L., Dodson R.J., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R.,
RA   Daugherty S.C., Brinkac L.M., Beanan M.J., Haft D.H., Nelson W.C.,
RA   Davidsen T.M., Zafar N., Zhou L., Liu J., Yuan Q., Khouri H.M.,
RA   Fedorova N.B., Tran B., Russell D., Berry K.J., Utterback T.R.,
RA   Van Aken S.E., Feldblyum T.V., D'Ascenzo M., Deng W.-L., Ramos A.R.,
RA   Alfano J.R., Cartinhour S., Chatterjee A.K., Delaney T.P., Lazarowitz S.G.,
RA   Martin G.B., Schneider D.J., Tang X., Bender C.L., White O., Fraser C.M.,
RA   Collmer A.;
RT   "The complete genome sequence of the Arabidopsis and tomato pathogen
RT   Pseudomonas syringae pv. tomato DC3000.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:10181-10186(2003).
CC   -!- FUNCTION: Multidrug efflux pump. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC       2.A.66.1) family. {ECO:0000305}.
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DR   EMBL; AE016853; AAO53669.1; -; Genomic_DNA.
DR   RefSeq; NP_789974.1; NC_004578.1.
DR   RefSeq; WP_011102995.1; NC_004578.1.
DR   AlphaFoldDB; Q88BA2; -.
DR   SMR; Q88BA2; -.
DR   STRING; 223283.PSPTO_0115; -.
DR   EnsemblBacteria; AAO53669; AAO53669; PSPTO_0115.
DR   GeneID; 1181723; -.
DR   KEGG; pst:PSPTO_0115; -.
DR   PATRIC; fig|223283.9.peg.119; -.
DR   eggNOG; COG0534; Bacteria.
DR   HOGENOM; CLU_012893_6_3_6; -.
DR   OMA; AAWFELF; -.
DR   OrthoDB; 1415498at2; -.
DR   PhylomeDB; Q88BA2; -.
DR   Proteomes; UP000002515; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR002528; MATE_fam.
DR   Pfam; PF01554; MatE; 2.
DR   PIRSF; PIRSF006603; DinF; 1.
DR   TIGRFAMs; TIGR00797; matE; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell inner membrane; Cell membrane; Ion transport; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..460
FT                   /note="Probable multidrug resistance protein NorM"
FT                   /id="PRO_0000164234"
FT   TRANSMEM        9..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        51..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        93..115
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        125..147
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        160..179
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        189..211
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        238..260
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        275..297
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        318..340
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        350..372
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        393..415
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        419..441
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   460 AA;  48844 MW;  28215731FD2FC469 CRC64;
     MQPPAFKELW IILRLAGPLI ASQMAHMLMV FTDTVMMGKI GPEALAGGGL GAATYSFISF
     FCVGVMAAVG TLVSIRHGAG DSEGVTRLTQ AGLWLAWGMA LIAALLLWNL EPILLQLGQA
     EANVHMAAQF LITLPFALPG LLSFMALRGF TSALGRAGPV MTISVAGAVA NFVLNYAMIN
     QWLGLPNLGL MGIGLVTAMV TNCMALALAW HIKRHPAYAA YPISKGLSKL SRSHLKELWR
     LGLPIGGTYA VEVGLFTFAA FCMGAMGSTQ MAAHQIALQT VSMAFMIPVG ISYAVTMRIG
     QHYGAGNILM ARTAGRLGIG FGGSVMLLFG IFFWLAPHWV IGLFLDLDDP AFAEIVVLAA
     KLLAIAAWFE FFDGTQTIAM GAIRGLKDAR TTFLIGLGCY WLIAAPAAWL LGFYADGGAS
     GVWWGLALGL FCSAVALTYA FEWKTARLLR KEAVGAAVPG