ID   NORM_RHILO              Reviewed;         467 AA.
AC   Q98D15;
DT   29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 1.
DT   25-MAY-2022, entry version 99.
DE   RecName: Full=Probable multidrug resistance protein NorM;
DE   AltName: Full=Multidrug-efflux transporter;
GN   Name=norM; OrderedLocusNames=mll4906;
OS   Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099)
OS   (Mesorhizobium loti (strain MAFF 303099)).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Phyllobacteriaceae; Mesorhizobium.
OX   NCBI_TaxID=266835;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LMG 29417 / CECT 9101 / MAFF 303099;
RX   PubMed=11214968; DOI=10.1093/dnares/7.6.331;
RA   Kaneko T., Nakamura Y., Sato S., Asamizu E., Kato T., Sasamoto S.,
RA   Watanabe A., Idesawa K., Ishikawa A., Kawashima K., Kimura T., Kishida Y.,
RA   Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Mochizuki Y.,
RA   Nakayama S., Nakazaki N., Shimpo S., Sugimoto M., Takeuchi C., Yamada M.,
RA   Tabata S.;
RT   "Complete genome structure of the nitrogen-fixing symbiotic bacterium
RT   Mesorhizobium loti.";
RL   DNA Res. 7:331-338(2000).
CC   -!- FUNCTION: Multidrug efflux pump. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC       2.A.66.1) family. {ECO:0000305}.
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DR   EMBL; BA000012; BAB51456.1; -; Genomic_DNA.
DR   RefSeq; WP_010912797.1; NC_002678.2.
DR   AlphaFoldDB; Q98D15; -.
DR   SMR; Q98D15; -.
DR   STRING; 266835.14024854; -.
DR   EnsemblBacteria; BAB51456; BAB51456; BAB51456.
DR   KEGG; mlo:mll4906; -.
DR   PATRIC; fig|266835.9.peg.3876; -.
DR   eggNOG; COG0534; Bacteria.
DR   HOGENOM; CLU_012893_6_3_5; -.
DR   OMA; EFWILLK; -.
DR   OrthoDB; 1415498at2; -.
DR   Proteomes; UP000000552; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR002528; MATE_fam.
DR   Pfam; PF01554; MatE; 2.
DR   PIRSF; PIRSF006603; DinF; 1.
DR   TIGRFAMs; TIGR00797; matE; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell inner membrane; Cell membrane; Ion transport; Membrane;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..467
FT                   /note="Probable multidrug resistance protein NorM"
FT                   /id="PRO_0000164235"
FT   TRANSMEM        23..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        62..84
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        104..126
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        141..163
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        170..192
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        202..224
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        250..272
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        287..309
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        330..352
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        367..384
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        405..427
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        432..454
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   467 AA;  50528 MW;  B93C7649AE0E30FE CRC64;
     MSAIDAGARA PENLWRQEIR ATLALAWPMV LTNLGQTAMT ATDVMMMGRL GPDTLASGAL
     GANLYFMPLI FGLGLMLATS PMIATELGRR RYSVRDLRRT VRQGLWLAIL ISIPIWIVLW
     HGEAILLAMG QEPALAHQAG IYLRWLEWAV LPFYGYIVLR SFISALERPG WALIIVFVAV
     ACNALFNWVF MFGNLGFPAM GIAGSGLATS LSSTLMFAGM AAVVMLEKKF RRYRLFGRFW
     RSDWPRFNGL LRLGLPIAGI LAFEVTIFNA AALLMGLIDA DSLAAHAIAI QIASISFMVP
     LGLNQAVTVR VGLAHGAGNP EGVSRAGWTA FVIGVSFMAL MGLVMVLWPH LLISAFIDLA
     NPANARVIAL AVSFLVFAAL FQVFDGAQAV AAGMLRGLHD TKVPMIYAAI GYWGVGLPLG
     VLLAFHFGFH GVGIWIGLSS GLAVVAALLL TRWLRRDRIA PPLAFGH