NORM_RHIME
ID NORM_RHIME Reviewed; 467 AA.
AC Q92PZ0;
DT 29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 25-MAY-2022, entry version 95.
DE RecName: Full=Probable multidrug resistance protein NorM;
DE AltName: Full=Multidrug-efflux transporter;
GN Name=norM; OrderedLocusNames=R01580; ORFNames=SMc01211;
OS Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium
OS meliloti).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX NCBI_TaxID=266834;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1021;
RX PubMed=11481430; DOI=10.1073/pnas.161294398;
RA Capela D., Barloy-Hubler F., Gouzy J., Bothe G., Ampe F., Batut J.,
RA Boistard P., Becker A., Boutry M., Cadieu E., Dreano S., Gloux S.,
RA Godrie T., Goffeau A., Kahn D., Kiss E., Lelaure V., Masuy D., Pohl T.,
RA Portetelle D., Puehler A., Purnelle B., Ramsperger U., Renard C.,
RA Thebault P., Vandenbol M., Weidner S., Galibert F.;
RT "Analysis of the chromosome sequence of the legume symbiont Sinorhizobium
RT meliloti strain 1021.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:9877-9882(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1021;
RX PubMed=11474104; DOI=10.1126/science.1060966;
RA Galibert F., Finan T.M., Long S.R., Puehler A., Abola P., Ampe F.,
RA Barloy-Hubler F., Barnett M.J., Becker A., Boistard P., Bothe G.,
RA Boutry M., Bowser L., Buhrmester J., Cadieu E., Capela D., Chain P.,
RA Cowie A., Davis R.W., Dreano S., Federspiel N.A., Fisher R.F., Gloux S.,
RA Godrie T., Goffeau A., Golding B., Gouzy J., Gurjal M., Hernandez-Lucas I.,
RA Hong A., Huizar L., Hyman R.W., Jones T., Kahn D., Kahn M.L., Kalman S.,
RA Keating D.H., Kiss E., Komp C., Lelaure V., Masuy D., Palm C., Peck M.C.,
RA Pohl T.M., Portetelle D., Purnelle B., Ramsperger U., Surzycki R.,
RA Thebault P., Vandenbol M., Vorhoelter F.J., Weidner S., Wells D.H.,
RA Wong K., Yeh K.-C., Batut J.;
RT "The composite genome of the legume symbiont Sinorhizobium meliloti.";
RL Science 293:668-672(2001).
CC -!- FUNCTION: Multidrug efflux pump. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC 2.A.66.1) family. {ECO:0000305}.
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DR EMBL; AL591688; CAC46159.1; -; Genomic_DNA.
DR RefSeq; NP_385686.1; NC_003047.1.
DR RefSeq; WP_010969319.1; NC_003047.1.
DR AlphaFoldDB; Q92PZ0; -.
DR SMR; Q92PZ0; -.
DR STRING; 266834.SMc01211; -.
DR EnsemblBacteria; CAC46159; CAC46159; SMc01211.
DR GeneID; 61603042; -.
DR KEGG; sme:SMc01211; -.
DR PATRIC; fig|266834.11.peg.3007; -.
DR eggNOG; COG0534; Bacteria.
DR HOGENOM; CLU_012893_6_3_5; -.
DR OMA; TGNQKVG; -.
DR Proteomes; UP000001976; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR002528; MATE_fam.
DR Pfam; PF01554; MatE; 2.
DR PIRSF; PIRSF006603; DinF; 1.
DR TIGRFAMs; TIGR00797; matE; 1.
PE 3: Inferred from homology;
KW Antiport; Cell inner membrane; Cell membrane; Ion transport; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..467
FT /note="Probable multidrug resistance protein NorM"
FT /id="PRO_0000164236"
FT TRANSMEM 20..42
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..79
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 107..129
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 144..163
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 170..192
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 202..224
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 250..272
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 292..314
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 326..348
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 368..390
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 403..425
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 429..451
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 467 AA; 49714 MW; 2F66AD79C66D7D9E CRC64;
MLTATKDLVL AQSDNSWPTH FRASLYLGVP FIGAQLAQLA INTTDVLMVG QLGATQLAAI
ILATQVFFTI FIFGSGFANA VVPMVAQAQG RGDQVSVRRS VRMGMWVVLL YGVLTAPVLW
MAEPILLFAG QKPEVAALAG EYLHIAQWAI FPSLIFMVLR AFLSGLERAG VILYVTLVTL
VLNAALCYVL IFGHFGFPEL GIFGAAVAAL GVALLGAALT IGYIRRQPEL HRFELFVRFW
RPDWPAFGEV VHLGIPISVT ILAEVSLFTV ASLLMGTIGT IELAAHGIAL QFASIAFMIP
LGLAQAGTVR IGLAYGSGDM VGVKRAAIAV LTLGVGFAAV GSTIFALFPH ELAGLYLDTR
RPDAAEVLAF AGPLIVIAGA FQLVDGLQAI AAGMLRGLKD TTIPMILAMI AYWPIGFFCA
WAFAFPLGFG GVGVWFGFVL GLASAALLLN WRFFRLLRRV SAAPAAS
