ID   NORM_RHOPA              Reviewed;         474 AA.
AC   Q6NB79;
DT   29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Probable multidrug resistance protein NorM;
DE   AltName: Full=Multidrug-efflux transporter;
GN   Name=norM; OrderedLocusNames=RPA0949;
OS   Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bradyrhizobiaceae; Rhodopseudomonas.
OX   NCBI_TaxID=258594;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-98 / CGA009;
RX   PubMed=14704707; DOI=10.1038/nbt923;
RA   Larimer F.W., Chain P., Hauser L., Lamerdin J.E., Malfatti S., Do L.,
RA   Land M.L., Pelletier D.A., Beatty J.T., Lang A.S., Tabita F.R.,
RA   Gibson J.L., Hanson T.E., Bobst C., Torres y Torres J.L., Peres C.,
RA   Harrison F.H., Gibson J., Harwood C.S.;
RT   "Complete genome sequence of the metabolically versatile photosynthetic
RT   bacterium Rhodopseudomonas palustris.";
RL   Nat. Biotechnol. 22:55-61(2004).
CC   -!- FUNCTION: Multidrug efflux pump. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC       2.A.66.1) family. {ECO:0000305}.
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DR   EMBL; BX572596; CAE26393.1; -; Genomic_DNA.
DR   RefSeq; WP_011156484.1; NC_005296.1.
DR   AlphaFoldDB; Q6NB79; -.
DR   SMR; Q6NB79; -.
DR   STRING; 258594.RPA0949; -.
DR   PRIDE; Q6NB79; -.
DR   EnsemblBacteria; CAE26393; CAE26393; RPA0949.
DR   GeneID; 66891968; -.
DR   KEGG; rpa:RPA0949; -.
DR   eggNOG; COG0534; Bacteria.
DR   HOGENOM; CLU_012893_6_3_5; -.
DR   OMA; TGNQKVG; -.
DR   PhylomeDB; Q6NB79; -.
DR   BioCyc; RPAL258594:TX73_RS04875-MON; -.
DR   Proteomes; UP000001426; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR002528; MATE_fam.
DR   Pfam; PF01554; MatE; 2.
DR   PIRSF; PIRSF006603; DinF; 1.
DR   TIGRFAMs; TIGR00797; matE; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell inner membrane; Cell membrane; Ion transport; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..474
FT                   /note="Probable multidrug resistance protein NorM"
FT                   /id="PRO_0000164237"
FT   TRANSMEM        33..50
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        65..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        108..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        150..172
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        179..201
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        211..233
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        258..280
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        295..317
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        334..356
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        376..398
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        410..432
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        436..458
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   474 AA;  49852 MW;  C57F275F091949A8 CRC64;
     MVRAMTAPGS NIAAGALAPA KSSAWRTELI ETLWLAWPMA LTQLGQIAMM TTDLALIGRL
     GDAAVAAAAL AHFVLFSTFT MGLGLVSAVT PLAAQAFGAR APRQVRASLR VGLWAGVIAG
     VPLTLGQLYG EELLVALGQN PATSRLAGDY LDGLAWSLVP GWLFIALRGL MGAVNRPEPA
     LWIMLTAIPI NLGLAYVLIH GSFGLPRLEI FGAGLATSIV SWAMCIAAAV VCVTMRPFRK
     YQVFGELFRF DGELMRRLLQ LGLPISGASV LEYGVFGAAA LLMGKFGTTA LAAHQIALQV
     AAIMFMVPMG ISVAATVRVG HAVGRGDPPS ARRAGFAAIG LGFVFMAAMT LLVALTRHQI
     PQLFLGDSDT SIETATLTAA LLIVGASFFI ADGLQVVANG ALRGRNDTKV PLLFAVLGFW
     VIGFPFCWVL GFHTDLGPFG VWIGLAVGLV VYAALLVWRF HRLTRDAMAA AVAA