ID   NORM_SHEON              Reviewed;         459 AA.
AC   Q8EES3;
DT   29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Probable multidrug resistance protein NorM;
DE   AltName: Full=Multidrug-efflux transporter;
GN   Name=norM; OrderedLocusNames=SO_2295;
OS   Shewanella oneidensis (strain MR-1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Shewanellaceae; Shewanella.
OX   NCBI_TaxID=211586;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MR-1;
RX   PubMed=12368813; DOI=10.1038/nbt749;
RA   Heidelberg J.F., Paulsen I.T., Nelson K.E., Gaidos E.J., Nelson W.C.,
RA   Read T.D., Eisen J.A., Seshadri R., Ward N.L., Methe B.A., Clayton R.A.,
RA   Meyer T., Tsapin A., Scott J., Beanan M.J., Brinkac L.M., Daugherty S.C.,
RA   DeBoy R.T., Dodson R.J., Durkin A.S., Haft D.H., Kolonay J.F., Madupu R.,
RA   Peterson J.D., Umayam L.A., White O., Wolf A.M., Vamathevan J.J.,
RA   Weidman J.F., Impraim M., Lee K., Berry K.J., Lee C., Mueller J.,
RA   Khouri H.M., Gill J., Utterback T.R., McDonald L.A., Feldblyum T.V.,
RA   Smith H.O., Venter J.C., Nealson K.H., Fraser C.M.;
RT   "Genome sequence of the dissimilatory metal ion-reducing bacterium
RT   Shewanella oneidensis.";
RL   Nat. Biotechnol. 20:1118-1123(2002).
CC   -!- FUNCTION: Multidrug efflux pump. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC       2.A.66.1) family. {ECO:0000305}.
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DR   EMBL; AE014299; AAN55335.1; -; Genomic_DNA.
DR   RefSeq; NP_717891.1; NC_004347.2.
DR   RefSeq; WP_011072297.1; NZ_CP053946.1.
DR   AlphaFoldDB; Q8EES3; -.
DR   SMR; Q8EES3; -.
DR   STRING; 211586.SO_2295; -.
DR   PaxDb; Q8EES3; -.
DR   KEGG; son:SO_2295; -.
DR   PATRIC; fig|211586.12.peg.2210; -.
DR   eggNOG; COG0534; Bacteria.
DR   HOGENOM; CLU_012893_6_0_6; -.
DR   OMA; TGNQKVG; -.
DR   OrthoDB; 1415498at2; -.
DR   PhylomeDB; Q8EES3; -.
DR   BioCyc; SONE211586:G1GMP-2097-MON; -.
DR   Proteomes; UP000008186; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0046677; P:response to antibiotic; IBA:GO_Central.
DR   InterPro; IPR002528; MATE_fam.
DR   Pfam; PF01554; MatE; 2.
DR   PIRSF; PIRSF006603; DinF; 1.
DR   TIGRFAMs; TIGR00797; matE; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell inner membrane; Cell membrane; Ion transport; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..459
FT                   /note="Probable multidrug resistance protein NorM"
FT                   /id="PRO_0000164238"
FT   TRANSMEM        12..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        46..68
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        89..111
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        121..143
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        155..177
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        187..209
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        244..266
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        281..303
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        316..335
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        350..372
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        385..407
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        417..439
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   459 AA;  49441 MW;  38F1E2C483FDBEC3 CRC64;
     MKHSGFQAKR LIQLALPVLI AQVTQTMMGF IDTVMAGRVS AVDMAAVAVG TSLWLPAILF
     VQGLLMAFTP LFAHHNGANN QKAIQPLAFQ GAYLALIGGL GVMVFLASAP LVLSHMNLEP
     QLYNLTIGYI DGILWGAPAF VLYQVLRGCS EGISYTLPTM VIGFVGLAVN IPANYIFIYG
     HFGIPAMGGA GCGIATALVF WAMLIAMAIY MQFHKKFAAL APFSQFHRPD FATMKKMTKL
     GLPIAMALFF EVSLFAIIAL LLAPLGATVV ASHQIALNFS AIVFMLPLSI GIAVSIRIGY
     YLGRDRADIS AVVAKVGLLL ALSLALSTAI LTVLFRFQIA ELYNSDPEVV VLAGSLMLMA
     ALYQLSDSVQ VVAAGALRGY KDTRSAFYIT LFSYWGIGMS LGYTLAYTDF IVPAMGAHGF
     WTGLIAGLTS AALLFFIRLR YIQKHRVHLS LIEGDSVHH