ID   NORM_STRPN              Reviewed;         453 AA.
AC   Q97QN5;
DT   29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Probable multidrug resistance protein NorM;
DE   AltName: Full=Multidrug-efflux transporter;
GN   Name=norM; OrderedLocusNames=SP_1166;
OS   Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=170187;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-334 / TIGR4;
RX   PubMed=11463916; DOI=10.1126/science.1061217;
RA   Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D.,
RA   Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J.,
RA   Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D.,
RA   Umayam L.A., White O., Salzberg S.L., Lewis M.R., Radune D.,
RA   Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L.,
RA   McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T., Hickey E.K.,
RA   Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A.,
RA   Morrison D.A., Hollingshead S.K., Fraser C.M.;
RT   "Complete genome sequence of a virulent isolate of Streptococcus
RT   pneumoniae.";
RL   Science 293:498-506(2001).
CC   -!- FUNCTION: Multidrug efflux pump. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC       2.A.66.1) family. {ECO:0000305}.
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DR   EMBL; AE005672; AAK75275.1; -; Genomic_DNA.
DR   PIR; B95135; B95135.
DR   RefSeq; WP_000278525.1; NC_003028.3.
DR   AlphaFoldDB; Q97QN5; -.
DR   SMR; Q97QN5; -.
DR   STRING; 170187.SP_1166; -.
DR   DNASU; 931680; -.
DR   EnsemblBacteria; AAK75275; AAK75275; SP_1166.
DR   KEGG; spn:SP_1166; -.
DR   eggNOG; COG0534; Bacteria.
DR   OMA; TGNQKVG; -.
DR   PhylomeDB; Q97QN5; -.
DR   BioCyc; SPNE170187:G1FZB-1185-MON; -.
DR   Proteomes; UP000000585; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR002528; MATE_fam.
DR   Pfam; PF01554; MatE; 2.
DR   PIRSF; PIRSF006603; DinF; 1.
DR   TIGRFAMs; TIGR00797; matE; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell membrane; Ion transport; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..453
FT                   /note="Probable multidrug resistance protein NorM"
FT                   /id="PRO_0000164239"
FT   TRANSMEM        12..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        54..76
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        96..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        128..150
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        162..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        194..216
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        243..265
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        285..307
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        319..338
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        358..380
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        387..404
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        414..436
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   453 AA;  50141 MW;  9F581B7DCBC91464 CRC64;
     MYKTKCLREK LVLFLKIFFP ILIYQFANYS ASFVDTAMTG QYNTMDLAGV SMATSIWNPF
     FTFLTGIVSA LVPIIGHHLG RGKKEEVASD FYQFIYLALG LSVVLLGMVL FLAPIILNHI
     GLEAAVAAVA VRYLWFLSIG IIPLLLFSVI RSLLDSLGLT KLSMYLMLLL LPLNSGFNYL
     LIYGAFGVPE LGGAGAGLGT SLAYWVLLGI SVLVLFKQEK LKALHLEKRI PLNMDKIKEG
     VRLGLPIGGT VFAEVAIFSV VGLIMAKFSP LIIASHQSAM NFSSLMYAFP MSISSAMAIV
     VSYEVGAKRF DDAKTYIGLG RWTALIFAAF TLTFLYIFRG NVASLYGNDP KFIDLTVRFL
     TYSLFFQLAD TFAAPLQGIL RGYKDTVIPF YLGLLGYWGV AIPVRTLFDS LTDFGAYSYW
     IGLIISLIVS GALYRWRLTV IMKRFESLAK SKC