ID   NORM_STRR6              Reviewed;         453 AA.
AC   Q8DPQ6;
DT   29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=Probable multidrug resistance protein NorM;
DE   AltName: Full=Multidrug-efflux transporter;
GN   Name=norM; OrderedLocusNames=spr1052;
OS   Streptococcus pneumoniae (strain ATCC BAA-255 / R6).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=171101;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-255 / R6;
RX   PubMed=11544234; DOI=10.1128/jb.183.19.5709-5717.2001;
RA   Hoskins J., Alborn W.E. Jr., Arnold J., Blaszczak L.C., Burgett S.,
RA   DeHoff B.S., Estrem S.T., Fritz L., Fu D.-J., Fuller W., Geringer C.,
RA   Gilmour R., Glass J.S., Khoja H., Kraft A.R., Lagace R.E., LeBlanc D.J.,
RA   Lee L.N., Lefkowitz E.J., Lu J., Matsushima P., McAhren S.M., McHenney M.,
RA   McLeaster K., Mundy C.W., Nicas T.I., Norris F.H., O'Gara M., Peery R.B.,
RA   Robertson G.T., Rockey P., Sun P.-M., Winkler M.E., Yang Y.,
RA   Young-Bellido M., Zhao G., Zook C.A., Baltz R.H., Jaskunas S.R.,
RA   Rosteck P.R. Jr., Skatrud P.L., Glass J.I.;
RT   "Genome of the bacterium Streptococcus pneumoniae strain R6.";
RL   J. Bacteriol. 183:5709-5717(2001).
CC   -!- FUNCTION: Multidrug efflux pump. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC       2.A.66.1) family. {ECO:0000305}.
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DR   EMBL; AE007317; AAK99856.1; -; Genomic_DNA.
DR   PIR; D98003; D98003.
DR   RefSeq; NP_358646.1; NC_003098.1.
DR   RefSeq; WP_000278532.1; NC_003098.1.
DR   AlphaFoldDB; Q8DPQ6; -.
DR   SMR; Q8DPQ6; -.
DR   STRING; 171101.spr1052; -.
DR   TCDB; 2.A.66.1.41; the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily.
DR   EnsemblBacteria; AAK99856; AAK99856; spr1052.
DR   GeneID; 60233493; -.
DR   KEGG; spr:spr1052; -.
DR   PATRIC; fig|171101.6.peg.1144; -.
DR   eggNOG; COG0534; Bacteria.
DR   HOGENOM; CLU_012893_6_0_9; -.
DR   OMA; TGNQKVG; -.
DR   Proteomes; UP000000586; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0046677; P:response to antibiotic; IBA:GO_Central.
DR   InterPro; IPR002528; MATE_fam.
DR   Pfam; PF01554; MatE; 2.
DR   PIRSF; PIRSF006603; DinF; 1.
DR   TIGRFAMs; TIGR00797; matE; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell membrane; Ion transport; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..453
FT                   /note="Probable multidrug resistance protein NorM"
FT                   /id="PRO_0000164240"
FT   TRANSMEM        12..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        54..76
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        96..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        128..150
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        162..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        194..216
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        243..265
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        285..307
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        319..338
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        358..380
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        387..406
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        416..438
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   453 AA;  50061 MW;  4FCC40E46634B2DB CRC64;
     MYKTKCLREK LVLFLKIFFP ILIYQFANYS ASFVDTAMTG QYNTMDLAGV SMATSIWNPF
     FTFLTGIVSA LVPIIGHHLG RGKKEEVASD FYQFIYLALG LSVVLLGMVL FLAPTILNHI
     GLEAAVAAVA VRYLWFLSIG IIPLLLFSVI RSLLDSLGLT KLSMYLMLLL LPLNSGFNYL
     LIYGAFGVPE LGGAGAGLGT SLAYWVLLGI SVLVLFKQEK LKALHLEKRI LLNMDKIKEG
     VRLGLPIGGT VFAEVAVFSV VGLIMAKFSS LIIASHQSAM NFSSLMYAFP MSISSAMAIV
     VSYEVGAKRF DDAKTYIGLG RWTALIFAAF TLTFLYIFRG NVASLYGNDP KFIDLTARFL
     TYSLFFQLAD TFAAPLQGIL RGYKDTVIPF YLGLLGYWGV AIPVATLFDS LTDFGAYSYW
     IGLIISLIVS GALYRWRLTV IMKRFESLAK SKR