ID   NORM_SYNP6              Reviewed;         464 AA.
AC   Q5MZD9;
DT   29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Probable multidrug resistance protein NorM;
DE   AltName: Full=Multidrug-efflux transporter;
GN   Name=norM; OrderedLocusNames=syc2391_d;
OS   Synechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1) (Anacystis
OS   nidulans).
OC   Bacteria; Cyanobacteria; Synechococcales; Synechococcaceae; Synechococcus.
OX   NCBI_TaxID=269084;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27144 / PCC 6301 / SAUG 1402/1;
RX   PubMed=17211581; DOI=10.1007/s11120-006-9122-4;
RA   Sugita C., Ogata K., Shikata M., Jikuya H., Takano J., Furumichi M.,
RA   Kanehisa M., Omata T., Sugiura M., Sugita M.;
RT   "Complete nucleotide sequence of the freshwater unicellular cyanobacterium
RT   Synechococcus elongatus PCC 6301 chromosome: gene content and
RT   organization.";
RL   Photosyn. Res. 93:55-67(2007).
CC   -!- FUNCTION: Multidrug efflux pump. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC       2.A.66.1) family. {ECO:0000305}.
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DR   EMBL; AP008231; BAD80581.1; -; Genomic_DNA.
DR   RefSeq; WP_011244701.1; NC_006576.1.
DR   AlphaFoldDB; Q5MZD9; -.
DR   SMR; Q5MZD9; -.
DR   STRING; 269084.syc2391_d; -.
DR   EnsemblBacteria; BAD80581; BAD80581; syc2391_d.
DR   KEGG; syc:syc2391_d; -.
DR   eggNOG; COG0534; Bacteria.
DR   OMA; TGNQKVG; -.
DR   Proteomes; UP000001175; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR002528; MATE_fam.
DR   Pfam; PF01554; MatE; 2.
DR   TIGRFAMs; TIGR00797; matE; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell inner membrane; Cell membrane; Ion transport; Membrane;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..464
FT                   /note="Probable multidrug resistance protein NorM"
FT                   /id="PRO_0000164241"
FT   TRANSMEM        13..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        52..74
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        94..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        131..153
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        160..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        192..214
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        244..266
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        281..303
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        315..337
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        352..373
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        394..416
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        421..443
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   464 AA;  49725 MW;  577F5A9ED11D3BA8 CRC64;
     MNLRTIRAEL QQFLQLAIPL AAAQVAQAAV GFVDTVMMGR LGPEPLAAGG LASALFQFIL
     ATASGVVMAV SPLVAEAQGA GKDYKIAAIA RQGLWLSVLL GLPVMLIISQ LARLMPVLGQ
     SATTIALARD YWMAVLWGII PGLGFAMLRG YVAALEQARI ILPLVLFGTL VNGLGNYLLG
     YGQLGFPRLE LTGLGLSSAL GLWVMFLGLL AYTAWQPKLR RYPFWQDWRR LQPSICRQIL
     QLGWAIAVTV AVEFGLFTII TILMGAIGVE ALAAHQTVSQ TIILIFMVPL GCSFAVTVRV
     GWWLGRQDGL GARRAGLVGV GAIALWMLLL AIPLALFPRA IVGIYVDLNN PVNAGLLNLA
     LPMLRVASLA LVLDGVQRVA MGALHGLQDT RIPLLLSLLA FWMVGVGSSA MLGFQLGWGS
     TGLWIGQSLG VAIAGGLFLQ RFLKLTQNRT FKQRLQPQPL ATHP